胶质母细胞瘤相关小胶质细胞研究现状

Research status of glioblastoma-associated microglia

小胶质细胞不同于巨噬细胞,具有独特的起源和作用。在胶质母细胞瘤中,小胶质细胞在调节肿瘤免疫状态、促进肿瘤血管生成、破坏血脑屏障及降低治疗敏感性等方面发挥了重要作用。因而在胶质母细胞瘤的放疗、化疗、免疫治疗中联合针对小胶质细胞的疗法也已成为具有临床前景的治疗方式。

Microglia differ from macrophages with unique origin and role.In glioblastoma,microglia plays an important role in regulating tumor immune status,promoting tumor angiogenesis,destroying the bloodbrain barrier,and reducing the sensitivity of treatment.Therefore,the combination of microglial therapy in the radiotherapy,chemotherapy and immunotherapy of glioblastoma has also become a clinically promising treatment.