P4HA2在促进肿瘤进展中的作用

Role of P4HA2in promoting cancerprogression

P4HA2是编码胶原蛋白脯氨酰4-羟化酶(C-P4H)的α亚基的重要基因之一,在多种肿瘤中过表达并促进肿瘤进展,其高表达与患者的不良预后相关。在不同肿瘤中,P4HA2可以促进肿瘤细胞增殖、迁移和侵袭能力,增加肿瘤干细胞群体的比例,以及促进肿瘤细胞免疫逃逸等。深入了解P4HA2在肿瘤进展中的作用,可为针对P4HA2预防或逆转肿瘤进展提供新的思路和见解。

P4HA2,one of the important genes encoding theαsubunit of collagen prolyl 4-hydroxylase(C-P4H),is overexpressed in a variety of tumors and promotes tumor progression,and its high expression correlates with the poor prognosis of patients.In different tumors,P4HA2 can promote the proliferation,migration and invasion of tumor cells,increase the proportion of cancer stem cell population,and promote tumor cells to escape from immune system.An in-depth understanding of the role of P4HA2 in tumor progression may provide new ideas and insights for targeting P4HA2 to prevent or reverse tumor progression.