肝移植治疗不可切除性直肠癌肝转移1例

Liver transplantation for liver metastasis of unresectable rectal cancer: one case report

本例不可切除性直肠癌肝转移患者确诊直肠癌时已合并肝内不可切除多发转移,切除原发病灶后采用FOLFOX方案化疗+贝伐珠单抗靶向治疗。2年后患者肝内转移灶增多增大,未见肝外转移灶及原位复发,实施肝移植手术,术后采用他克莫司+西罗莫司免疫抑制方案,雷替曲塞化疗。肝移植3年后,本例患者肿瘤复发,总生存期为6年。本例提示,对于不可切除性结直肠癌肝转移患者,在未发现原位复发及其他远隔转移的情况下实施肝移植手术可以提高患者的生活质量并获得较好的预后。

This report described one case of applying liver transplantation(LT)in for liver metastases of unresectable rectal cancer.The recipient had multiple intrahepatic metastases upon a diagnosis of colorectal cancer.FOLFOX chemotherapy plus bevacizumab targeted therapy were offered after a resection of primary lesion.Two years later,intrahepatic metastases expanded while no extrahepatic metastasis or in situ recurrence was noted.After LT,tacrolimus+sirolimus immunosuppression regimen and chemotherapy of rhatitrexed were prescribed.Tumor recurred at 3 years after LT and the survival time was 6 years.For patients with unresectable liver metastases of colorectal cancer,LT in the absence of orthotopic recurrence and other distant metastases may improve patient quality-of-life and achieve better outcomes.