宫颈癌相关长链非编码RNA及其信号通路的研究进展

Research progress of cervical cancer associated long non-coding RNA and its signaling pathway

近年来,通过完善筛查系统以及接种人乳头瘤病毒疫苗,宫颈癌的发病率显著下降,但其仍是导致女性死亡的主要原因之一。晚期肿瘤转移及耐药性是宫颈癌患者死亡的主要原因,因此,深入了解宫颈癌发展过程中的分子机制可能为宫颈癌治疗提供新的方向。据报道,长链非编码RNA(lncRNAs)是许多生物过程中的关键调节因子,它是一种长度超过200个核苷酸但不能编码蛋白质的RNA,可以在转录、翻译和翻译后水平上执行多种功能。LncRNA在癌症表达失调,被认为是癌症中潜在的生物标志物和治疗靶点。本文就lncRNA在宫颈癌中的调节机制及其在调节高度保守的信号通路中的作用机制进行讨论,为宫颈癌的诊断治疗提供新的思路。

The incidence of cervical cancer has declined significantly in recent years through improved screening systems and human papillomavirus(HPV)vaccination,but it remains one of the leading causes of death among women.Advanced stage,metastasis and drug-resistance are the main causes of death in cervical cancer patients.Therefore,a thorough understanding of the molecular mechanisms in the development of cervical cancer may provide new directions for the treatment of cervical cancer.It has been reported that long non-coding RNAs(lncRNAs)are emerging as important regulators in many biological processes.LncRNAs are a group of RNA with more than 200 nucleotides in length but cannot encode proteins,which can perform a variety of functions at the transcriptional,translational and post-translational levels.Dysregulated lncRNA can serve as potential biomarker and therapeutic target in cancer.This article discusses the regulatory mechanism of lncRAN in cervical cancer and its role in regulating highly conserved signaling pathways,so as to provide new ideas for the diagnosis and treatment of cervical cancer.