中性粒细胞/淋巴细胞比值在继发性肾脏疾病中的研究进展

Research progress of neutrophil-to-lymphocyte ratio in secondary kidney diseases

继发性肾脏疾病在我国以狼疮性肾炎、紫癜性肾炎、乙肝病毒相关性肾炎及糖尿病肾病最为常见,是导致终末期肾衰竭的重要原因,早期诊断及治疗对疾病预后尤为重要。研究表明,炎症是肾脏疾病发生和发展的重要原因,中性粒细胞/淋巴细胞比值(NLR)是近年来备受关注的新型炎症标志物,已有研究发现,NLR是原发性肾脏疾病严重程度及预后的重要预测因子之一。本文就NLR在常见继发性肾脏疾病中的研究进展进行综述。

Lupus nephritis,Henoch-Schonlein purpura nephritis,hepatitis B virus-associated glomerulonephritis(HBV-GN)and diabetic kidney disease are the most common secondary kidney diseases in China,which are the important causes of end-stage renal failure.Early diagnosis and treatment are particularly important for disease prognosis.The researches have implicated inflammation as a key factor in the occurrence and development of kidney diseases.Neutrophil-to-lymphocyte ratio(NLR)is a new inflammatory marker that has attracted much attention in recent years and has been found to be one of the important predictors of the severity and prognosis of primary kidney diseases.This article reviews the recent advances in the research of NLR in common secondary kidney diseases.