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多光子显微技术在乳腺癌预后预测的应用

Application of Multiphoton Microscopy in Prognostic Prediction of Breast Cancer
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摘要 乳腺癌是全世界最广泛的女性癌症类型,同样也是女性癌症死亡的主要原因。2020年乳腺癌发病数已经超过肺癌,成为了全球第一大癌。多光子显微技术(MPM)是基于激光与生物组织相互作用发生的多光子激发荧光和谐波等非线性光学效应的一种先进医学成像技术。多光子显微技术不但在成像分辨率上具有与组织病理学分辨率相当的优势,而且具有无标记、免切片、光学层析成像、反映细胞的功能代谢信息、三维靶向消融能力、较低的光漂白与光损伤、高成像对比度等优势。因此,多光子显微技术在医学病理诊断,特别是肿瘤病理诊断临床转化的基础研究和应用研究领域一直受到广泛的关注。本文详细阐述了多光子显微技术在乳腺肿瘤微环境预后预测研究中的应用进展,并展望了其未来发展前景。 Breast cancer is the most common type of cancer in women worldwide and the leading cause of cancer death in women,which has surpassed lung cancer as the leading type of cancer worldwide in 2020.Multiphoton microscopy(MPM)is an advanced medical imaging technique based on nonlinear optical effects,such as multiphoton excited fluorescence and harmonic generation,occurring owing to laser interactions with biological tissues.MPM offers the advantage of a resolution comparable to digital histopathology as well as requires no labeling or sectioning while providing three-dimensional optical imaging that reflects the metabolic function information of cells,threedimensional targeted ablation ca-pability,low photobleaching and photodamage,and a high imaging contrast.Therefore,MPM has gar-nered considerable research interest locally and globally in the field of basic and applied research in medical pathological diagnosis,particularly in the clinical translation of tumor pathological diagnosis.Herein,the application progress of MPM in the prognostic prediction of breast tumor microenvironments is introduced in detail and its future development prospects are presented.
作者 罗添忆 詹惠玲 许铭宇 徐顺武 何佳佳 李连煌 韩侠辉 郑莉琴 陈建新 卓双木 席刚琴 Tianyi Luo;HuiLing Zhan;Mingyu Xu;Shunwu Xu;Jiajia He;Lianhuang Li;Xiahui Han;Zhenli Qin;Jianxin Chen;Shuangmu Zhuo;Gangqin Xi(School of Science,Jimei University.Xiamen 361000;School of Electronic and Mechanical Engineering,Fujian Polytechnic Normal University,Fuqing 350300,China;Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education,Fujian Provincial Key Laboratory for Photonics Technology,College of Photonic and Electronic Engineering,Fujian Normal University,Fuzhou,350007,China)
出处 《福光技术》 2022年第1期19-26,共8页 FUJIAN OPTICAL TECHNOLOGY
关键词 医用光学 多光子显微技术 乳腺癌 肿瘤微环境 预后预测 medical optics multiphoton microscopy breast cancer tumor microenvironment progno-sis and prediction
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