DWI在鼻咽癌疗效预测中的研究进展

Research advances of DWI in response prediction of nasopharyngeal carcinoma

鼻咽癌(nasopharyngeal carcinoma,NPC)因其分期不同而采用的治疗方案有所不同,早期预测疗效能及时调整治疗方案和进行补救治疗。扩散加权成像(diffusion weighted imaging,DWI)可利用水分子扩散率产生对比度,揭示肿瘤微观结构的额外信息。由DWI获得的表观扩散系数(apparent diffusion coefficient,ADC)可定量描述人体内水分子扩散运动速度和范围,更加直观地解释疾病信息,对NPC疗效预测具有重要价值。本文对DWI及其相关技术如体素内非相干运动DWI、扩散峰度成像和分段读出平面回波成像技术进行简单介绍,并综述其和相关影像组学研究在NPC疗效预测中的研究进展,以期能为临床医生制订治疗决策提供参考,并指导未来的研究方向。

Nasopharyngeal carcinoma(NPC)is treated differently depending on its stage,early prediction of curative effect enables timely adjustment of treatment plan and rescue therapy.Diffusion weighted imaging(DWI)can detect the degree of water molecules diffusion to reveal additional information on tumor microstructure.The apparent diffusion coefficient(ADC)obtained by DWI can quantitatively describe the speed and range of the diffusion movement of water molecules in the human body,and interpret disease information more intuitively,playing an important role in the response prediction of NPC.We briefly introduced DWI and its related techniques,such as incoherent motion DWI,diffusion kurtosis imaging and readout segmentation of long variable echo-trains,and reviews the progress of its and related radiomics studies in predicting the response of NPC in this paper,in order to provide reference value for clinicians to make treatment decisions and guide the future research direction.