A型肉毒毒素在增生性瘢痕防治中的研究进展

Botulinum toxin type A for the prevention and treatment of hypertrophic scars:updated review

增生性瘢痕因其发病率高、易复发,且无法完全去除,一直是烧伤整形科的一大难题。近年来,研究发现A型肉毒毒素(BTX-A)具有减轻创面周围张力,抑制成纤维细胞的增殖,促进其凋亡及胶原纤维降解,减少创面血管生成,减轻创面周围炎症反应等作用,以此来抑制瘢痕增生。且BTX-A不良反应少、安全性高,联合曲安奈德、激光等方法治疗瘢痕可获得较好的效果。该文对BTX-A防治增生性瘢痕的研究进展进行综述,以期为增生性瘢痕的治疗提供新的思路。

Hypertrophic scar is the most common scar in the clinic.Due to its high incidence,high rate of recurrence,and difficulty of complete removal,it has always been a major problem in the department of burn and plastic surgery.In recent years,some scholars have found that botulinum toxin type A(BTX-A)can inhibit scar hyperplasia by reducing the tension around the wound,inhibiting the proliferation of fibroblasts,promoting their apoptosis,promoting the degradation of collagen fibers,reducing wound angiogenesis,reducing inflammation around the wound and other mechanisms.BTX-A has fewer adverse reactions and high safety.Additionally,its effect combined with triamcinolone acetonide and laser in treating scars is significant.Therefore,it has been widely used in the treatment of hypertrophic scars.In this paper,the research progress of BTX-A in the prevention and treatment of hypertrophic scar was reviewed in order to provide new ideas for the treatment of hypertrophic scar.