Ivan de Araujo团队揭示GLP-1如何通过肠脑轴神经环路调控机体行为和生理学效应

A New Study From Ivan de Araujo Lab Reported GLP-1 Mediated Gut-Brain Neural Circuit Controls Appetite Suppression

近期来自西奈山医学院IvandeAraujo课题组报道了小肠分泌的内生型胰高血糖素样肽1(GLP-1)通过交感神经通路控制食欲的器官间神经环路,该工作证实了远端回肠L细胞内分泌的GLP-1是由位于肌层的表达GLP-1R(胰高血糖素-1受体)的神经元监测,并通过腹腔交感神经节,进而介导胃动力减低和扩张。该文进一步深入研究并发现,位于脊髓的背根神经元,是感受胃扩张,并将感觉信息传导至延髓,从而引发下丘脑与脑干协同的降低摄食行为。这项研究为治疗腹胀,食欲减退等胃动力障碍的相关疾病提供了新的策略。

A new study in Cell from Ivan de Araujo and colleagues reported that intestinal GLP-1 acts on an inter-or⁃gan sympathetic neural circuit that induces appetite suppression.This study revealed that GLP-1,secreted by ileal L cells,sensing by intestinal myenteric layer intestinofugal neurons activated a sympatho-gastro-spinal-reticular-hypotha⁃lamic pathway involved in appetite suppression,linking stomach distention to craniofacial programs for food rejection.These molecularly indentified,delimited enteric circuits may be targeted to ameliorate the abdominal bloating and loss of appetite typical of gastric motility disorders.