血清25羟维生素D在2型糖尿病合并代谢综合征中的临床意义

Clinical Significance of Serum 25 Hydroxyvitamin D in the Combined Metabolic Syndrome of Type 2 Diabetes Mellitus

目的探讨血清25-羟维生素D[25-(OH)D]水平在2型糖尿病(type 2 diabetes mellitus,T2DM)合并代谢综合征(metabolic syndrome,MS)中的价值,为临床诊断提供理论依据。方法收集2021年4月—2022年4月在皖南医学院第二附属医院住院的92例T2DM患者的临床资料,将其分成两组,观察组(n=46)为T2DM合并MS,对照组(n=46)为单纯T2DM。收集并比较两组患者的基线资料、相关生化指标及血清25-(OH)D水平。采用Logistic回归模型评估T2DM合并MS的发生发展的独立影响因素及受试者工作特征曲线(receiver operating characteristic curve,ROC)评估血清25-(OH)D对其预测效能。结果观察组血清25-(OH)D水平低于对照组,差异有统计学意义(t=4.469,P<0.001)。ROC曲线显示25-(OH)D对T2DM合并MS的AUC为0.748,灵敏度为97.8%,有一定的辅助诊断作用。结论血清25-(OH)D对T2DM患者合并MS的发生及发展具有预测价值,可用于辅助T2DM合并MS的诊断。

Objective To explore the value of serum 25 hydroxyvitamin D[25-(OH)D]level in type 2 diabetes(T2DM)with metabolic syndrome(MS),and provide theoretical basis for clinical diagnosis.Methods The clinical data of 92 T2DM patients hospitalized in the Second Affiliated Hospital of Wannan Medical College from April 2021 to April 2022 were collected and divided into two groups,the observation group(n=46)with T2DM combined with MS and the control group(n=46)with T2DM alone.Baseline data,relevant biochemical indices and serum 25-(OH)D levels were collected and compared between the two groups.Logistic regression models were used to assess the independent factors influencing the development of MS in T2DM combined with MS and to evaluate the predictive efficacy of serum 25-(OH)D on the receiver operating characteristic curve(ROC).Results The serum 25-(OH)D level in the observation group was lower than that in the control group,and the difference was statistically significant(t=4.469,P<0.001).The ROC curve showed that 25-(OH)D had an AUC of 0.748 and a sensitivity of 97.8%for T2DM combined with MS,which had a certain auxiliary diagnostic effect.Conclusion Serum 25-(OH)D has predictive value for the occurrence and development of T2DM patients with MS,and can be used to assist in the diagnosis of T2DM with MS.