达格列净联合二甲双胍缓释片治疗糖尿病合并慢阻肺稳定期患者的效果分析

Effect Analysis of Dapagliflozin Combined with Metformin Extendedrelease Tablets in the Treatment of Patients with Diabetes Mellitus Combined with Stable Stage of Chronic Obstructive Pulmonary Disease

目的分析达格列净联合二甲双胍缓释片治疗糖尿病合并慢阻肺稳定期患者的效果。方法选取邹城市人民医院2020年8月—2022年8月收治的82例糖尿病合并慢阻肺稳定期患者为研究对象,利用黑白摸球法随机分为对照组(41例)和观察组(41例)。均接受呼吸康复训练,对照组给予二甲双胍缓释片治疗,观察组在对照组基础上联合达格列净治疗。比较两组治疗效果。结果治疗前,两组患者空腹血糖、餐后2 h血糖、糖化血红蛋白水平比较,差异无统计学意义(P>0.05)。治疗后,两组血糖水平均明显低于治疗前,且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者FINs、HOMA-β、HOMA-IR比较,差异无统计学意义(P>0.05)。治疗后,两组患者FINs、HOMA-β高于治疗前,HOMA-IR均低于治疗前,且观察组均优于对照组,差异有统计学意义(P<0.05)。观察组总有效率(97.56%)比对照组(82.93%)明显更高,差异有统计学意义(P<0.05)。结论达格列净与二甲双胍缓释片联合治疗糖尿病合并慢阻肺稳定期患者效果明显,可显著降低血糖水平,改善胰岛素抵抗。

Objective To analyze the effect of dapagliflozin combined with metformin extended-release tablets in the treatment of patients with diabetes mellitus combined with stable stage of chronic obstructive pulmonary disease.Methods Eighty two patients with diabetes complicated with chronic obstructive pulmonary disease(COPD)in stable stage who were admitted to Zoucheng People's Hospital from August 2020 to August 2022 were selected as the research objects.They were randomly divided into the control group(41 cases)and the observation group(41 cases)by black and white ball touching method.All patients received respiratory rehabilitation training.The control group was treated with Metformin sustained-release tablets,and the observation group was treated with Dapagliflozin on the basis of the control group.Compare the treatment effects between the two groups.Results Before treatment,there was no statistically significant difference between the two groups in the levels of fasting blood glucose,blood glucose 2 hours after meal,and glycated hemoglobin(P>0.05).After treatment,the blood glucose levels of the two groups were significantly lower than those before treatment,and the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in FINs,HOMA-βand HOMA-IR between the groups(P>0.05).After treatment,FINs and HOMA in both groups of patients-βBoth were higher than before treatment,while HOMA-IR was lower than before treatment,and the observation group was better than the control group,the difference was statistically significant(P<0.05).The total effective rate of the observation group(97.56%)was significantly higher than that of the control group(82.93%),and the difference was statistically significant(P<0.05).Conclusion The combination of dapagliflozin and metformin extended-release tablets was effective in treating patients with diabetes mellitus combined with stable stage of chronic obstructive pulmonary disease,significantly reducing blood glucose level and improving insulin resistance.