变应性鼻炎合并气道高反应性的风险因素研究进展

Risk factors for the development of airway hyperresponsiveness in patients with allergic rhinitis

变应性鼻炎(allergic rhinitis,AR)是过敏性哮喘的独立风险因素之一。部分AR患者可能合并气道高反应性(airway hyperresponsiveness,AHR)但并无哮喘症状。这种无典型哮喘症状的AHR常常被忽略。探索AR合并AHR的临床相关风险因素,以及预测AR患者出现AHR的生物标志物,对预防AHR及哮喘的发生具有重要意义。本文总结了AR合并AHR的风险因素的研究进展,以期为AR患者预防AHR提供思路。

Allergic rhinitis(AR)is an independent risk factor for allergic asthma.Some AR patients may have developed airway hyperresponsiveness(AHR)in the absence of asthma symptoms.In this stage,AHR is often neglected due to the absence of typical asthma symptoms.Exploring the clinically relevant risk factors for AHR in patients with AR,as well as the clinical indicators and biomarkers to predict AHR in patients with AR,is of great significance to the prevention of the occurrence of AHR and asthma.This review summarized the risk factors for the development of AHR in AR patients,and gave hints to the prevention of AHR in AR patients.