具有过氧化物酶活性的纳米酶及其在生物分子检测中的应用

Nanozyme with Peroxidase Activity and Its Application in Biomolecule Detection

目前人工合成纳米酶取得了相当大的进展。纳米酶具有合成工艺简单、价格低、储存时间长、环境稳定性高等显著优点。多种具有过氧化物酶活性的纳米酶已被广泛应用于生物传感、免疫分析、癌症诊断和治疗、神经保护、干细胞生长等医学领域。为了突出纳米酶在生物分子检测领域的发展,从具有过氧化物酶活性纳米酶的分类及其在生物分子检测中的应用两方面综述了近年来研究者们取得的突出成果。此外,依据纳米酶的研究现状,讨论了纳米酶技术遇到的挑战,展望了未来的发展方向,并提出了一些思考与建议。

In the past few decades,considerable progress has been made in the synthesis of nanozymes.Nanozymes have the remarkable advantages of simple synthesis process,low price,long storage time and high environmental stability.A variety of nanozymes with peroxidase activity have been widely used in biosensing,immunoassay,cancer diagnosis and therapy,neuroprotection,stem cell growth and other medical fields.In order to highlight the development of nanozymes in the field of biomolecule detection,this paper reviews the outstanding achievements of researchers in recent years from the classification of nanozymes with peroxidase activity and their application in biomolecule detection.In addition,according to the research status of nanozyme,the challenges encountered by nanozyme technology are discussed,the future development direction is prospected,and some thoughts and suggestions are put forward.