依达拉奉联合中风皂贝化痰胶囊治疗急性脑梗死疗效观察

Curative effect of edaravone plus apoplexy zaobei resolving phlegm capsule in the treatment of acute cerebral infarction

目的 探讨依达拉奉联合中风皂贝化痰胶囊治疗老年急性脑梗死患者的效果和对血清白细胞介素-6、基质金属蛋白酶-9水平及生活自理能力的影响。方法 将74例老年急性脑梗死患者按治疗方案不同分为研究组30例和对照组44例。对照组给予依达拉奉治疗,研究组给予依达拉奉联合中风皂贝化痰胶囊治疗。回顾性观察并分析患者血清白细胞介素-6、基质金属蛋白酶-9水平及神经功能缺损、生活自理能力改善情况等。结果 治疗后两组患者血清白细胞介素-6、基质金属蛋白酶-9水平、美国国立卫生研究院卒中量表评分及中枢神经特异蛋白、神经元特异性烯醇化酶检测结果较治疗前降低,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗后两组患者简易精神状态评价量表、蒙特利尔认知评估量表、日常生活能力量表评分较治疗前升高,且研究组高于对照组,差异均有统计学意义(P<0.05)。结论 依达拉奉联合中风皂贝化痰胶囊治疗老年急性脑梗死患者,可使患者血清白细胞介素-6、基质金属蛋白酶-9水平降低,改善患者神经功能,提高总疗效,改善预后。

Objective To explore the therapeutic effect of edaravone plus apoplexy zaobei resolving phlegm capsule(AZRPC)in the treatment of acute cerebral infarction(ACI)and its influences on serum interleukin-6(IL-6)and matrix metalloproteinase-9(MMP-9)levels as well as self-care ability of daily life.Methods Seventy-four senile ACI patients were divided into research(n=30)and control(n=44)group according to different therapeutic regimens.Control group received edaravone treatment and research did edaravone plus the AZRPC.Serum IL-6 and MMP-9 levels,neurological deficit,and the improvements of self-care ability were retrospectively observed and analyzed.Results After treatment IL-6 and MMP-9 levels,scores on the National Institutes of Health Stroke Scale,and central nervous specific protein and neuron-specific enolase detection results in both groups lowered compared with pre-treatment,those were lower in research than control group,and differences were statistically significant(P<0.05).After treatment scores on the Mini-Mental State Examination,Montreal Cognitive Assessment,and Activities of Daily Living Scale in both groups elevated compared with pre-treatment,those were higher in research than control group,and differences were statistically significant(P<0.05).Conclusion Edaravone plus the AZRPC could lower serum IL-6 and MMP-9 levels of senile ACI patients,improve neurological function,raise overall efficacy,and improve prognosis.