莨菪碱注射液辅助阿奇霉素序贯疗法在小儿支原体肺炎治疗中的作用评价

Evaluation of the Effect of Hyoscyamine Injection Assisted Sequential Azithromycin Therapy in the Treatment of Children with Mycoplasma Pneumonia

目的:目的:探讨莨菪碱注射液辅助阿奇霉素序贯疗法在小儿支原体肺炎治疗中的作用。方法:选取2019年12月—2020年12月临沂市中医医院收治的小儿支原体肺炎者60例为研究对象,采用抽签法随机分为参照组于研究组,参照组应用阿奇霉素序贯疗法,研究组在参照组基础上采用莨菪碱注射液治疗。比较两组治疗效果。结果:研究组治疗后用力肺活量、第1秒用力呼气容积占预计值的百分、第1秒用力呼气容积/用力肺活量均高于参照组,差异有统计学意义(P<0.05)。研究组治疗总有效率高于参照组,差异有统计学意义(P=0.0195)。研究组治愈时间、体温恢复正常时间、咳嗽症状消失时间、肺部啰音消失时间短于参照组,差异有统计学意义(P<0.001)。研究组摄氧量(VO2)、心率、氧脉搏、无氧阈、通气量、二氧化碳通气当量、VO2变化与功率变化比值均优于参照组,差异有统计学意义(P<0.001)。结论:小儿支原体肺炎患者实施莨菪碱注射液联合阿奇霉素序贯疗法,可改善临床症状,提高治疗有效率。

Objective:To explore the effect of hyoscyamine injection assisted sequential azithromycin therapy in the treatment of children with mycoplasma pneumonia.Methods:From December 2019 to December 2020,sixty children with mycoplasma pneumonia admitted to Linyi Hospital of Traditional Chinese Medicine in Province were selected as the research objects.They were randomly divided into a reference group and a study group by drawing lots.The reference group was treated with azithromycin sequential therapy,and the study group was treated with hyoscyamine injection on the basis of the reference group.The treatment effects of the two groups were compared.Results:After treatment,the forced vital capacity,the percentage of the forced expiratory volume in the first second to the predicted value,and the forced expiratory volume/forced vital capacity in the first second in the study group were higher than those in the reference group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the study group was higher than that in the reference group,and the difference was statistically significant(P=0.0195).The recovery time,body temperature recovery time,cough symptom disappearance time,and pulmonary rales disappearance time in the study group were shorter than those in the reference group,and the difference was statistically significant(P<0.001).The oxygen uptake(VO2),heart rate,oxygen pulse,anaerobic threshold,ventilation volume,carbon dioxide ventilation equivalent,ratio of VO2 change to power change in the study group were all better than those in the reference group,and the difference was statistically significant(P<0.001).Conclusion:Sequential therapy of hyoscyamine injection combined with azithromycin for children with mycoplasma pneumonia can improve clinical symptoms and increase the effective rate of treatment.