G蛋白偶联胆汁酸受体1调控机体炎症信号通路的研究进展

Research Progress on the G-Protein-Coupled Bile Acid Receptor 1 Regulating Inflammatory Signal Pathways in Organism

G蛋白偶联胆汁酸受体1(GPBAR1)与胆汁酸(BAs)及其衍生物结合后,激活下游通路传导,调控动物的多种代谢过程。GPBAR1通过核转录因子κB(NF-κB)、信号转导和转录激活因子3(STAT3)、NOD样受体蛋白3(NLRP3)炎症小体信号转导通路,调节动物体炎症反应。因此,本文重点阐述GPBAR1对动物炎症通路的调控进展,为BAs及其衍生物成为治疗炎症性疾病的潜在药物提供参考。

The G-protein-coupled bile acid receptor 1(GPBAR1)binding to bile acids(BAs)and their derivatives can activate the downstream pathways to regulate various metabolic processes.GPBAR1 regulates inflammation in animals by nuclear factor kappa-B(NF-κB),signal transducer and activator of transcription 3(STAT3)and NOD like receptor protein 3(NLRP3)signal transduction pathways.Therefore,the article focuses on the regulation of GPBAR1 in inflammation,in order to provide a reference for BAs and their derivatives becoming the potential drug for the treatment of inflammatory diseases.