摘要
G蛋白偶联胆汁酸受体1(GPBAR1)与胆汁酸(BAs)及其衍生物结合后,激活下游通路传导,调控动物的多种代谢过程。GPBAR1通过核转录因子κB(NF-κB)、信号转导和转录激活因子3(STAT3)、NOD样受体蛋白3(NLRP3)炎症小体信号转导通路,调节动物体炎症反应。因此,本文重点阐述GPBAR1对动物炎症通路的调控进展,为BAs及其衍生物成为治疗炎症性疾病的潜在药物提供参考。
The G-protein-coupled bile acid receptor 1(GPBAR1)binding to bile acids(BAs)and their derivatives can activate the downstream pathways to regulate various metabolic processes.GPBAR1 regulates inflammation in animals by nuclear factor kappa-B(NF-κB),signal transducer and activator of transcription 3(STAT3)and NOD like receptor protein 3(NLRP3)signal transduction pathways.Therefore,the article focuses on the regulation of GPBAR1 in inflammation,in order to provide a reference for BAs and their derivatives becoming the potential drug for the treatment of inflammatory diseases.
作者
何孟娟
黎力之
幸清凤
关玮琨
廖晓鹏
张海波
郭冬生
樊庆灿
HE Mengjuan;LI Lizhi;XING Qingfeng;GUAN Weikun;LIAO Xiaopeng;ZHANG Haibo;GUO Dongsheng;FAN Qingcan(College of Life Science and Resources and Environment,Yichun University,Jiangxi Yichun 336000,China)
出处
《中国畜牧杂志》
CAS
CSCD
北大核心
2023年第7期59-63,69,共6页
Chinese Journal of Animal Science
基金
国家地区科学基金(32060773、32160804)
江西省自然科学基金(20202BABL205010、20224BAB215037)
江西省教育厅项目(GJJ190848、GJJ201621)。