精神病未治期及其早期干预的研究进展

Advances in Duration of Untreated Psychosis and Its Early Intervention

精神病通常涉及一系列与职业或社会功能受损有关的认知、行为和情感症状。未治期是影响精神病患者预后的重要预测因素和独立危险因素,较长的未治期与疾病不良预后相关,缩短未治期的早期干预措施也逐渐受到国内外研究者的关注。本文回顾分析了精神病未治期的相关研究,阐述了未治期的概念、测量工具、神经生物学机制、未治期与精神病预后的关系及缩短未治期的早期干预措施,为临床针对精神病未治期的相关干预策略提供思路和依据。

Mental illness usually involves a range of cognitive,behavioral,and affective symptoms associated with impaired occupational or social functioning.Duration of untreated psychosis(DUP)is considered as an important predictor and independent risk factor for the prognosis of patients with mental disorders,a longer DUP is associated with poor prognosis.Meanwhile,early intervention measures to shorten DUP have gradually attracted increasing attention from both domestic and international researchers.In this paper,the related studies on DUP were reviewed and analyzed,the concept,measurement tools,neurobiological mechanisms of DUP,the relationship between DUP and prognosis,and early intervention measures to shorten DUP were described,in order to provide ideas and reference for developing clinical intervention strategies for DUP.