氨基酮戊酸光动力疗法对皮肤寻常疣HBD-2及炎性因子水平的影响

Effect of aminolevulinic acid photodynamic therapy on HBD-2 and inflammatory factors in verruca vulgaris

目的观察皮肤寻常疣采用氨基酮戊酸光动力治疗对人β-防御素-2(HBD-2)及炎性因子水平的影响。方法选取2021年1月—2023年1月开封市人民医院收治的108例皮肤寻常疣患者,将液氮冷冻治疗的54例作为对照组,将氨基酮戊酸光动力治疗的54例作为观察组,观察且对比两组治疗前后人β-防御素-2(HBD-2)的水平、炎性因子的水平、疗效、复发率及不良反应的发生率。结果(1)从HBD-2的水平观察,治疗前及治疗刚结束,两组差异无统计学意义(P>0.05),治疗后3个月,观察组与对照组相比明显降低,组间有显著性差异(P<0.05)。(2)从炎性因子的水平观察,治疗前,两组差异无统计学意义(P>0.05),治疗后3个月,观察组与对照组对比明显降低,组间差异有统计学意义(P<0.05)。(3)从治疗疗效观察,观察组总有效率为96.30%,对照组总有效率为83.33%,对比显示观察组明显高于对照组,组间差异有统计学意义(P<0.05)。(4)从复发率观察,观察组治疗后1、2、3个月的复发率均显然低于对照组,组间差异有统计学意义(P<0.05)。(5)从不良反应的发生率观察,观察组不良反应发生率(7.41%)与对照组(9.26%)相比差异无统计学意义(P>0.05)。结论皮肤寻常疣治疗中应用氨基酮戊酸光动力疗法可表现出明显的疗效,且复发率低。

Objective To observe the effects of photodynamic treatment with aminophenone valerate on the levels of humanβ-defensin-2(HBD-2)and inflammatory factors.Methods A total of 108 patients with common cutaneous warts admited to Kaifeng Peoples Hospital from January 2021 to January 2023 were selected.54 patients treated with liquid nitrogen cryotherapy were selected as control group,and 54 patients treated with aminolevulinic acid photodynamic therapy were selected as observation group.The levels ofβ-defensin-2(HBD-2),inflammatory factors,efficacy,recurrence rate and incidence of adverse reactions were observed and compared between the two groups before and after treatment.Results From the observation of HBD-2 level,before treatment and just after treatment,there was no statistical significance between the two groups(P>0.05),3 months after treatment,the observation group was obviously lower than that of the control group,there was a significant difference between the two groups(P<0.05).From the observation level of inflammatory factors,before treatment,there was no statistical significance between the two groups(P>0.05),3 months after treatment,the observation group and control group significantly decreased,the difference between the two groups was statistically significant(P<0.05).③From the observation of therapeutic effect,the total effective rate of the observation group was 96.30%,and the total effective rate of the control group was 83.33%.The comparison showed that the observation group was significantly higher than the control group,and the difference between groups was statistically significant(P<0.05).④From the observation of recurrence rate,the recurrence rate of the observation group 1,2 and 3 months after treatmentwas significantly lowerthan that of the control group,and the difference between the groups was statistically significant(P<0.05).In terms of the incidence of adverse reactions,there was no significant difference between the observation group(7.41%)and the control group(9.26%)(P>0.05).Conclusion Photodynamic therapy with amino ketovalerate is effective and has a low recurrence rate in the treatment of common wart.