维生素D信号通路关键基因研究进展

Research progress on key genes of vitamin D signaling pathway

近年来,有关维生素D信号通路骨骼外作用的报道逐渐增多。研究表明,维生素D信号通路在基因组与非基因组效应上均可不同程度参与体内钙稳态、骨骼内效应、细胞增殖、分化、氧化应激、血管生成、炎症反应、免疫调节、抗菌肽的产生及识别等过程。本文综述了维生素D受体信号通路中GC、CYP2R1、CYP24A1、CYP27B1、VDR及RXRα等关键基因的相关研究进展,以期更准确、全面了解该通路的生理、病理学机制,并为进一步研究奠定基础。

In recent years,more and more reports have been reported on the extracellular role of vitamin D signaling pathway.Studies have shown that both genomic and non‐genomic effects of vitamin D signaling pathway are involved in calcium homeostasis,skeletal effects,cell proliferation,differentiation,oxidative stress,angiogenesis,inflammatory response,immune regulation,production and recognition of antimicrobial peptides to varying degrees.This paper reviews the research progress of key genes such as GC,CYP2R1,CYP24A1,CYP27B1,VDR and RXRαin vitamin D receptor signaling pathway,in order to understand the physiological and pathological mechanisms of this pathway more accurately and comprehensively,and lay a foundation for further research.