期刊文献+

胆囊结石患者发生意外胆囊癌的临床分析

Risk factors of incidental gallbladder cancer in patients with gallstone
下载PDF
导出
摘要 目的分析胆囊结石患者发生意外胆囊癌的因素。方法收集2016年12月至2022年8月湖州市中心医院患胆囊结石、择期行胆囊切除手术的患者8010例,其中意外胆囊癌患者33例(观察组),按1∶4随机抽取胆囊结石伴胆囊炎患者132例作为对照组。比较两组患者基础指标(包括性别、年龄、BMI、是否合并糖尿病、高血压、胆道结石)以及血液学指标[血清钠(Na+)、尿素氮(BUN)、肌酐(Cr)、白蛋白(ALB)、TBil、DBil、ALT、AST、ALP、WBC、Hb、PLT、国际标准化比值(INR)、PT、D-二聚体(D-D)、糖类抗原19-9(CA19-9)]的差异。结果观察组患者年龄、BMI、合并糖尿病比例均明显高于对照组,差异均有统计学意义(均P<0.05)。观察组患者ALB水平明显低于对照组,AST、ALP、D-D水平及CA19-9异常比例明显高于对照组,差异均有统计学意义(均P<0.05)。结论意外胆囊癌更可能在年龄较大(>65岁)、BMI偏高、合并糖尿病的胆囊结石患者中发生,伴有AST、ALP、D-D、CA19-9水平升高及ALB水平降低。 Objective To explore the factors associated with the occurrence of incidental gallbladder cancer(IGBC)in patients with gallstones.Methods A total of 8010 patients with cholecystolithiasis who underwent elective cholecystectomy in Huzhou Central Hospital from December 2016 to August 2022 were enrolled,including 33 cases with incidental gallbladder cancer(study group)and 132 cases randomly selected among gallstone patients with cholecystitis at 1∶4 ratio(control group).The basic indicators(including gender,age,BMI,comorbid diabetes,hypertension and biliary stones),and hematological indicators(Na+,BUN,Cr,ALB,TBil,DBil,ALT,AST,ALP,WBC,Hb,PLT,INR,PT,D-D,CA19-9)were compared between two groups.Results The age,BMI and comorbid diabetes in study group were significantly higher than those in the control group(all P<0.05).The ALB levels of the study group were significantly lower than those of the control group,while the AST,ALP,D-D and CA19-9 levels were significantly higher than those of the control group(all P<0.05).Conclusion Incidental gallbladder cancer is more likely to occur in patients with older age,comorbid diabetes and increased BMI,AST,ALP,D-D,CA19-9 and decreased ALB levels.
作者 潘治平 孙旭 岑峰 严强 PAN Zhiping;SUN Xu;CEN Feng;YAN Qiang(Department of General Surgery,Huzhou Central Hospital(Affiliated Huzhou Hospital,Zhejiang University School of Medicine),Huzhou 313000,China;不详)
出处 《浙江医学》 CAS 2023年第13期1401-1404,共4页 Zhejiang Medical Journal
关键词 胆囊癌 意外胆囊癌 胆囊结石 Gallbladder cancer Incidental gallbladder cancer Gallstone
  • 引文网络
  • 相关文献

参考文献3

二级参考文献31

  • 1Danielle M. Hari,J. Harrison Howard,Anna M. Leung,Connie G. Chui,Myung‐Shin Sim,Anton J. Bilchik.A 21‐year analysis of stage I gallbladder carcinoma: is cholecystectomy alone adequate?[J]. HPB . 2012 (1)
  • 2Peter S. Hammerman,Michael S. Lawrence,Douglas Voet.Comprehensive genomic characterization of squamous cell lung cancers. Nature . 2012
  • 3European Association for the Study of the Liver.EASL Clinical Practice Guidelines: Management of cholestatic liver diseases[J].Journal of Hepatology.2009(2)
  • 4Thorsten Oliver Goetze,Vittorio Paolucci.Adequate extent in radical re-resection of incidental gallbladder carcinoma: analysis of the German Registry[J].Surgical Endoscopy.2010(9)
  • 5Wolin Kathleen Y,Carson Kenneth,Colditz Graham A.Obesity and cancer. The Oncologist . 2010
  • 6EC Lazcano-Ponce,JF Miquel,N Mun?oz,R Herrero,C Ferrecio,II Wistuba,Alonso de Ruiz P,Aristi Urista G,F Nervi.Epidemiology and molecular pathology of gallbladder cancer. CA: a cancer journal for clinicians . 2001
  • 7William C. Gallahan,Jason D. Conway.Diagnosis and Management of Gallbladder Polyps[J]. Gastroenterology Clinics of North America . 2010 (2)
  • 8Andrea Cariati,Elisa Piromalli,Francesco Cetta.Gallbladder cancers: associated conditions, histological types, prognosis, and prevention[J]. European Journal of Gastroenterology & Hepatology . 2014 (5)
  • 9M. D’Hondt,R. Lapointe,Z. Benamira,H. Pottel,M. Plasse,R. Letourneau,A. Roy,M. Dagenais,F. Vandenbroucke-Menu.Carcinoma of the gallbladder: Patterns of presentation, prognostic factors and survival rate. An 11-year single centre experience[J]. European Journal of Surgical Oncology . 2013 (6)
  • 10Thorsten Goetze,Vittorio Paolucci.The prognostic impact of positive lymph nodes in stages T1 to T3 incidental gallbladder carcinoma: results of the German Registry[J]. Surgical Endoscopy . 2012 (5)

共引文献238

;
使用帮助 返回顶部