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2014—2020年北京地区全血献血者HBV相关标记物检测结果分析 被引量:1

Analysis of detection results of HBV-related markers in whole blood donors of Beijing from 2014 to 2020
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摘要 目的 探讨2014—2020年北京地区全血献血者HBV相关标记物检测情况,为更好地开展本地区无偿献血者管理提供科学依据。方法 选取2014年1月至2020年12月北京市红十字血液中心登记的预备献血人群2 022 749名,分析其献血前HBsAg初筛、献血后HBsAg复检、HBV-DNA、ALT检测结果及人口学特征。结果 2 022 749例预备献血者中,男1 456 379名(72.00%),女566 370名(28.00%),年龄18~60岁,平均(24.0±6.0)岁。HBV总不合格率为1.37%,其中献血前HBsAg初筛不合格率为1.10%,献血后HBV不合格率为0.33%;献血人群HBV总不合格率由2014年的2.06%逐年下降至2020年的0.66%;单位团体献血者献血前HBsAg初筛不合格率低于街头个人献血者(0.46%比1.24%),两者分别由2014年的0.66%、1.89%下降至2020年的0.23%、0.50%,差异均有统计学意义(P<0.05)。5 518名血液复检HBV不合格的献血者中,重复献血者占比10.22%。结论 献血前初筛和献血后血液复检降低了输血传染HBV风险。团体献血者及重复献血者是HBV相对低危的献血人群。 Objective To explore the detection of HBV in whole blood donors of Beijing from 2014 to 2020,and provide scientific basis for better management of unpaid blood donors.Methods A total of 2 022 749 registered blood donors in Beijing Red Cross Blood Center from January 2014 to December 2020 were selected,and the results of HBsAg screening before blood donation,HBsAg recheck after blood donation,HBV-DNA and ALT detection were analyzed,and the demographic characteristics were analyzed.Results There were 1 456 379 males(72.00%) and 566 370 females(28.00%)among the 2 022 749 prospective blood donors,aged from 18 to 60 years,with an average age of(24.0 ± 6.0) years.The total unqualified rate of HBV was 1.37%.The unqualified rate of HBsAg screening was 1.10% before blood donation and 0.33%after blood donation.The total unqualified rate of HBV in blood donors decreased from 2.06% in 2014 to 0.66% in 2020.The unqualified rate of HBsAg screening before blood donation in unit group was lower than that in street individual donors(0.46% vs.1.24%),and both of them decreased from 0.66% and 1.89% in 2014 to 0.23% and 0.50% in 2020,respectively,with statistical significance(P<0.05).Among 5 518 blood donors who failed to pass the HBV re-examination,10.22% were repeated donors.Conclusions The risk of HBV infection through blood transfusion is reduced by screening before and rechecking after blood donation.Group blood donors and repeat blood donors are relatively low risk HBV blood donors.
作者 陈霄 毕岐勇 江峰 邱艳 Chen Xiao;Bi Qiyong;Jiang Feng;Qiu Yan(Department of Whole Blood Collection,Beijing Red Cross Blood Center,Beijing 100088,China)
出处 《北京医学》 CAS 2023年第4期347-350,共4页 Beijing Medical Journal
关键词 乙型肝炎病毒 献血者 HBV blood donor
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