摘要
Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products(NPs),and despite an ever-increasing number of unknown NPs have been discovered over the past few decades,much of the hidden biosynthetic potential is still in an urgent need to be disclosed.In this research,a chemical inves-tigation was performed on a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05,leading to the isolation of a total of fourteen drimane sesquiterpenoids(1-14),incorporating three new ones,namely ustusols F-H(1-3).Their structures,comprising absolute configurations,were completely authenticated by widespread spectroscopic data,quantum chemical 13C NMR and ECD calculations,and X-ray crystallography experiments.Compound 14 exhibited moderate anti-inflammatory activity by inhibiting the LPS-induced NO release(IC_(50)=25.6μM).
基金
The National Natural Science Foundation for Distinguished Young Scholars,81725021,Yonghui Zhang
the National Natural Science Foundation of China,Nos.81573316,31870326
the Innovative Research Groups of the National Natural Science Foundation of China,No.81721005,Yonghui Zhang
the Fundamental Research Funds for the Central Universities,No.2020kfyXJJS083,Zhengxi Hu
the National Key R&D Program of China,No.2021YFA0910500,Yonghui Zhang
the Research and Development Program of Hubei Province,No.2020BCA058,Jianping Wang
the Chinese Medicine Research Foundation of Health Commission of Hubei Province,No.ZY2021Z019,Jianping Wang.
