陕西省男男同性性行为人群HIV暴露前预防知识知晓及用药意愿调查

A survey on awareness of and willingness to use HIV pre-exposure prophylaxis among men who have sex with men in Shaanxi province

目的 调查分析陕西省男男同性性行为人群(men who have sex with men, MSM)对人类免疫缺陷病毒(human immunodeficiency virus,HIV)暴露前预防用药(pre-exposure prophylaxis,PrEP)的知晓情况和用药意愿。方法 采用横断面调查方法,2021年6—12月采用网络填写问卷的方法对陕西省MSM状况进行问卷调查并分析。结果 共获得有效问卷820份。PrEP知识知晓率为54.88%,陕西省不同学历(χ^(2)=29.188, P<0.01)、婚姻状态(χ^(2)=11.984, P=0.017)、性取向(χ^(2)=9.460, P<0.01)、性伴类别(χ^(2)=17.530, P<0.01)、与性伴的安全套使用情况(χ^(2)=12.220, P<0.01)的MSM之间PrEP知识知晓率差异有统计学意义。PrEP使用意愿为47.56%,不同学历(χ^(2)=11.083,P=0.011)、职业(χ^(2)=17.589, P=0.040)、收入(χ^(2)=11.175, P=0.011)的MSM之间使用意愿率差异有统计学意义。二分类多因素logistic回归分析显示,本科及以上/大专学历(OR=0.58,95%CI:0.36~0.93,P=0.024)、高中/中专学历(OR=0.54,95%CI:0.37~0.79,P=0.002)、有时使用安全套(OR=3.10, 95%CI:1.28~7.49, P=0.012)是PrEP知识知晓的影响因素;大学本科及以上/大专学历(OR=0.64,95%CI:0.42~0.97,P=0.033)是影响PrEP使用意愿的影响因素。结论 陕西省MSM对PrEP的知晓率和使用意愿普遍偏低,有必要加强PrEP的宣传和提高MSM对PrEP接受率。

Objective To investigate the awareness of HIV pre-exposure prophylaxis(PrEP) and willingness to use PrEP among men who have sex with men(MSM) in Shaanxi province. Methods This study was a cross-sectional survey. MSM were recruited and investigated through online questionnaire. Results A total of 820 valid questionnaires were obtained. The awareness rate of PrEP knowledge was 54. 88%. There were statistically significant differences in the awareness rate of PrEP knowledge among MSM with different educational level(χ^(2)=29. 188,P<0. 01), marital status(χ^(2)=11. 984,P=0. 017), sexual orientation(χ^(2)=9. 460,P<0. 01), sexual partner type(χ^(2)=17. 530,P<0. 01), and condom use with sexual partners(χ^(2)=12. 220,P<0. 01) in Shaanxi province. The willingness to use PrEP was 47. 56%, with statistically significant differences among MSM with different education level(χ^(2)=11. 083,P=0. 011), different occupation(χ^(2)=17. 589,P=0. 040), and different income level(χ^(2)=11. 175,P=0. 011). Multivariable logistic regression showed that,having a bachelor degree or above/college degree(OR=0. 58, 95%CI: 0. 36-0. 93, P=0. 024), having a high school/technical secondary school degree(OR=0. 54, 95%CI: 0. 37-0. 79, P=0. 002), and sometimes using condoms(OR=3. 10, 95%CI: 1. 28-7. 49, P=0. 012) were the influencing factors of PrEP knowledge awareness. Having a college degree or above(OR=0. 64, 95%CI: 0. 42-0. 97, P=0. 033) was the influencing factor of willingness to use PrEP. Conclusions The awareness rate and usage of PrEP among MSM in Shaanxi province are generally low. It is necessary to expand the publicity of PrEP and promote the uptake of PrEP among MSM.