青年体检人群高尿酸血症的检出情况及其影响因素分析

Analysis of the detection of hyperuricemia and its influencing factors in young people undergoing physical examination

目的探究青年体检人群高尿酸血症(HUA)的检出情况,并分析HUA的相关影响因素。方法选取在广西壮族自治区人民医院健康管理中心进行健康体检的53136名青年体检者为研究对象,比较不同特征青年人群HUA检出情况,应用二分类非条件logistic回归分析对影响HUA的因素进行分析。结果青年体检者HUA的检出率为25.73%(13672/53136)。不同性别、体质量指数、腰围身高比、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、血肌酐情况的青年体检者的HUA检出率差异均有统计学意义(均P<0.05)。二分类非条件logistic回归分析结果显示:男性、超重/肥胖、腰围身高比异常、总胆固醇升高、甘油三酯升高、低密度脂蛋白升高、高密度脂蛋白降低、血肌酐升高均是发生HUA的独立危险因素(均P<0.05)。结论青年体检人群的HUA检出率较高,男性、超重/肥胖、腰围身高比异常、血脂异常、血肌酐升高均是发生HUA的独立危险因素。

Objective To explore the detection of hyperuricemia(HUA)in young people undergoing physical examination and to analyze the relevant influencing factors for HUA.Method A total of 53136 young people undergoing physical examination at the Health Management Center of the People's Hospital of Guangxi Zhuang Autonomous Region were selected as the research subjects.The detection of HUA in young people with different characteristics was compared.Binary classification unconditional logistic regression analysis was used for factors affecting HUA.Results The detection rate of HUA among young people undergoing physical examination was 25.73%(13672/53136).There were statistically significant differences in the HUA detection rate among young people undergoing physical examination with different genders,body mass indexes,waist-to-height ratios,levels of fasting blood glucose,total cholesterol,triglyceride,low-density lipoprotein,high-density lipoprotein,and serum creatinine(all P<0.05).The results of binary classification unconditional logistic regression analysis showed that male,overweight/obese,an abnormal waist-to-height ratio,elevated total cholesterol,triglyceride,low-density lipoprotein levels,a decreased high-density lipoprotein level,and an elevated serum creatinine level were independent risk factors for HUA(all P<0.05).Conclusion The detection rate of HUA in young people undergoing physical examination was quite high,and male,overweight/obese,an abnormal waist-to-height ratio,dyslipidemia,and an elevated serum creatinine level were independent risk factors for HUA.