性别因素对复合芬太尼时环泊酚用于胃镜检查术麻醉效力的影响

Effect of gender on anesthetic potency of ciprofol for gastroscopy when combined with fentanyl

目的:评价性别因素对复合芬太尼时环泊酚用于胃镜检查麻醉效力的影响。方法:选择静脉麻醉下行胃镜检查术的患者,年龄18~50岁,体质量指数18~25 kg/m^(2),ASA分级Ⅰ或Ⅱ级,按照性别分为男性组(M组)及女性组(F组)。静脉注射芬太尼1.5μg/kg后,采用序贯法进行环泊酚给药,静脉注射初始剂量为0.4 mg/kg,剂量调整梯度为0.04 mg/kg。采用probit回归分析法计算环泊酚用于胃镜检查术麻醉的ED_(50)和95%可信区间。结果:F组环泊酚ED_(50)(95%可信区间)为0.33(0.32~0.34)mg/kg,M组为0.27(0.26~0.28)mg/kg,2组ED_(50)比较差异无统计学意义(P>0.05)。结论:复合芬太尼(1.5μg/kg)时环泊酚用于胃镜检查术的麻醉效力无明显性别差异(ED_(50):女性0.33 mg/kg,男性0.27 mg/kg)。

Objective To evaluate the effect of gender on anesthetic potency of ciprofol for gastroscopy when combined with fentanyl.MethodsAmerican Society of Anesthesiologists Physical Status classificationⅠorⅡpatients,aged 18-50 yr,with body mass index of 18-25 kg/m^(2),undergoing elective gastroscopy with intravenous anesthesia,were divided into 2 groups according to gender:male group(M group)and female group(F group).After fentanyl 1.5μg/kg was intravenously injected,ciprofol was given by the Dixon′s up-and-down method,with the initial dose of 0.4 mg/kg followed by dose increment/decrement of 0.04 mg/kg.The ED_(50) and 95%confidence interval of ciprofol for gastroscopy anesthesia were calculated by the probit regression analysis.ResultsThe ED_(50)(95%confidence interval)of ciprofol for gastroscopy was 0.33(0.32-0.34)mg/kg in F group and 0.27(0.26-0.28)mg/kg in M patients when combined with fentanyl 1.5μg/kg.There was no significant difference between the two groups(P>0.05).ConclusionsThere is no significant gender difference in the anesthetic potency of ciprofol for gastroscopy(ED_(50):female 0.33 mg/kg,male 0.27 mg/kg)when combined with fentanyl(1.5μg/kg).