残余尿量对非肌层浸润性膀胱癌患者复发的影响

Effect of residual urine volume on recurrence in patients with non-muscle invasive bladder cancer

目的:探讨良性前列腺增生(benign prostatic hyperplasia,BPH)导致的膀胱残余尿量(residual urine volume,RUV)对男性非肌层浸润性膀胱癌(non-muscle invasive bladder cancer,NMIBC)患者术后肿瘤复发的影响。方法:选取2018年1月至2020年6月在胜利油田中心医院泌尿外科行经尿道膀胱肿瘤电切术(transurethral resection of bladder tumor,TURBT)的男性NMIBC患者113例为研究对象。记录患者临床及病理资料,包括国际前列腺症状评分(international prostate symptom score,IPSS)、最大尿流率(maximum urinary flow rate,Q_(max))及RUV等情况。采用Kaplan-Meier法分析RUV与术后肿瘤复发的关系。采用Cox风险回归模型分析影响男性NMIBC患者术后肿瘤复发的独立危险因素。结果:113例男性NMIBC患者术后平均随访时间为(24.86±7.17)个月;高RUV组和低RUV组肿瘤复发例数分别为37例和18例,高RUV组术后肿瘤复发率高于低RUV组(P<0.05);Kaplan-Meier法分析表明,高RUV组肿瘤无复发累积生存率低于低RUV组(P<0.05);Cox风险回归模型分析显示,RUV为男性NMIBC患者术后复发独立危险因素(P<0.05)。结论:高RUV可增加男性NMIBC患者的肿瘤复发风险。

Objective:To investigate the effect of urinary residual volume(RUV)induced by benign prostatic hyperplasia(BPH)on postoperative tumor recurrence in male patients with non-muscle invasive bladder cancer(NMIBC).Methods:113 male NMIBC patients who underwent transurethral resection of bladder tumor(TURBT)in the urology department of Shengli Oilfield Central Hospital from January 2018 to June 2020 were selected as the study subjects.The clinical and pathological data of patients were recorded,including the international prostate symptom score(IPSS),the maximum urinary flow rate(Q_(max))and RUV.Kaplan-Meier method was used to analyze the relationship between RUV and postoperative tumor recurrence.Cox risk regression model was used to analyze the independent risk factors of tumor recurrence in male NMIBC patients after operation.Results:The average follow-up time of 113 male patients with NMIBC was(24.86±7.17)months.The number of tumor recurrence in the high RUV group and the low RUV group was 37 and 18,respectively.The rate of tumor recurrence in the high RUV group was higher than that in the low RUV group(P<0.05).Kaplan-Meier analysis showed that the cumulative recurrence free survival rate of tumor in the high RUV group was lower than that in the low RUV group(P<0.05).Cox risk regression model analysis showed that RUV was an independent risk factor for postoperative recurrence in male NMIBC patients(P<0.05).Conclusion:High RUV can increase the risk of tumor recurrence in male NMIBC patients.