急性早幼粒细胞白血病中弹性蛋白酶和组织蛋白酶的研究进展

Research progress of neutrophil elastase and cathepsin G in acute promyelocytic leukemia

急性早幼粒细胞白血病(APL)独特的形态学特征为骨髓中以颗粒增多的早幼粒细胞为主,早幼粒细胞中富含嗜天青颗粒,其内含大量的弹性蛋白酶(NE)和组织蛋白酶G(CatG),两者在APL的外周血及骨髓血中高表达,对NE及CatG的研究发现了其与APL的发生发展及靶向治疗的相关性。现从NE与APL的发生及CatG与APL的关系两方面对增多的嗜天青颗粒中NE和CatG在APL中的研究进展进行综述。

The unique morphological feature of acute promyelocytic leukemia(APL)is that the bone marrow is dominated by promyelocytes with increased granules,and the promyelocytes are rich in azurophilic granules,which contain a large amount of neutrophil elastase(NE)and cathepsin G(CatG),both of which are highly expressed in the peripheral blood and bone marrow blood of APL.Studies on NE and CatG have found their correlation with the occurrence and development of APL and targeted therapy.This paper reviews the research progress of NE and CatG in APL from the occurrence of APL with NE and the relationship between CatG and APL.