葛酮通络胶囊联合针刺治疗急性缺血性脑卒中临床研究

Clinical Study on Getong Tongluo Capsules Combined with Acupuncture for Acute Ischemic Stroke

目的:观察葛酮通络胶囊联合针刺治疗对急性缺血性脑卒中(AIS)患者神经功能及氧化应激水平的影响。方法:将100例AIS患者按随机数字表法分为对照组、葛酮组、针刺组、联合组,每组25例。对照组给予一般治疗和专科治疗,葛酮组在对照组基础上给予葛酮通络胶囊治疗,针刺组在对照组基础上给予针刺治疗,联合组在对照组基础上给予葛酮通络胶囊联合针刺治疗,4组均连续治疗14 d。比较4组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、神经功能缺损指标[S-100B蛋白、神经元特异性烯醇化酶(NSE)、神经胶质纤维酸性蛋白(GFAP)]及氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、8-羟基脱氧鸟苷(8-OHDG)、丙二醛(MDA)]水平。结果:治疗后,4组NIHSS评分均较治疗前降低(P<0.05),葛酮组、针刺组及联合组NIHSS评分均低于对照组(P<0.05),联合组NIHSS评分均低于葛酮组及针刺组(P<0.05)。治疗后,4组血清S-100B蛋白、NSE、GFAP水平均较治疗前降低(P<0.05),葛酮组、针刺组及联合组血清S-100B蛋白、NSE、GFAP水平均低于对照组(P<0.05),联合组血清S-100B蛋白、NSE、GFAP水平均低于葛酮组及针刺组(P<0.05)。治疗后,4组血清SOD、GSH-Px水平均较治疗前升高(P<0.05),血清MDA、8-OHDG水平均较治疗前降低(P<0.05);葛酮组、针刺组及联合组血清SOD、GSH-Px水平均高于对照组(P<0.05),血清MDA、8-OHDG水平均低于对照组(P<0.05);联合组血清SOD、GSH-Px水平均高于葛酮组及针刺组(P<0.05),血清MDA、8-OHDG水平均低于葛酮组及针刺组(P<0.05)。结论:葛酮通络胶囊联合针刺治疗可有效改善AIS患者的神经功能缺损程度及氧化应激指标。

Objective:To observe the effect of Getong Tongluo Capsules combined with acupuncture on levels of neurological function and oxidative stress in patients with acute ischemic stroke(AIS).Methods:A total of 100 cases of AIS patients were divided into the control group,the Getong group,the acupuncture group,and the combination group according to the random number table method,with 25 cases in each group.The control group was given general treatment and specialized treatment;the Getong group was additionally given Getong Tongluo Capsules based on the treatment of the control group;the acupuncture group was additionally treated with acupuncture based on the treatment of the control group;the combination group was additionally treated with Getong Tongluo Capsules combined with acupuncture based on the treatment of the control group.All the 4 groups were treated for 14 days continuously. National Institutes of Health Stroke Scale (NIHSS) scores,levels of neurological impairmentindexes [S-100B protein,neuron-specific enolase (NSE),and glial fibrillary acidic protein (GFAP)],and oxidativestress indexes [glutathione peroxidase (GSH-Px),superoxide dismutase (SOD),8-hydroxydeoxyguanosine(8-OHDG),and malondialdehyde (MDA)] in the 4 groups were compared before and after treatment. Results:After treatment, NIHSS scores in the 4 groups were decreased when compared with those beforetreatment (P<0.05);NIHSS scores in the Getong group, the acupuncture group, and the combinationgroup were lower than that in the control group (P<0.05),and NIHSS score in the combination group werelower than those in the Getong group and the acupuncture group (P<0.05). After treatment,the levels ofS- 100B protein,NSE,and GFAP in serum in the 4 groups were decreased when compared with thosebefore treatment (P<0.05);the levels of S-100B protein,NSE,and GFAP in serum in the Getong group,the acupuncture group,and the combination group were lower than those in the control group (P<0.05),and the levels of S- 100B protein, NSE, and GFAP in serum in the combination group were lower thanthose in the Getong group and the acupuncture group (P<0.05). After treatment, the levels of SOD andGSH-Px in serum in the 4 groups were increased when compared with those before treatment (P<0.05),and the levels of MDA and 8- OHDG in serum were decreased when compared with those beforetreatment (P<0.05);the levels of SOD and GSH- Px in serum in the Getong group, the acupuncturegroup,and the combination group were higher than those in the control group (P<0.05),and the levels ofMDA and 8-OHDG in serum were lower than those in the control group (P<0.05);the levels of SOD andGSH-Px in serum in the combination group were higher than those in the Getong group and the acupuncturegroup (P<0.05);the levels of MDA and 8-OHDG in serum in the combination group were lower than thosein the Getong group and the acupuncture group (P<0.05). Conclusion:Getong Tongluo Capsules combinedwith acupuncture for AIS patients can effectively improve the degree of neurological deficit and oxidativestress indexes.