新滋水平肝饮与针刺联合多巴丝肼片治疗肝肾不足型帕金森病临床研究

Clinical Study on Xin Zishui Pinggan Decoction and Acupuncture Combined with Levodopa Benserazide Tablets for Parkinson's Disease of Liver and Kidney Insufficiency Type

目的:观察新滋水平肝饮与针刺联合多巴丝肼片治疗肝肾不足型帕金森病的效果。方法:将112例肝肾不足型帕金森病患者随机分为中医组和西医组。西医组接受多巴丝肼片治疗,中医组在多巴丝肼片基础上加用新滋水平肝饮联合针刺治疗,2组均连续治疗12周。比较2组临床疗效,治疗前后评定中医证候积分、统一帕金森病评定量表(UPDRS)评分,测量P300潜伏期和波幅,检测神经递质[多巴胺(DA)、5-羟色胺(5-HT)、神经营养因子3(NT-3)],统计治疗期间的不良反应发生率。结果:治疗后,中医组临床疗效总有效率高于西医组(P<0.05)。2组中医证候积分、UPDRS评分均较治疗前降低(P<0.05),中医组中医证候积分、UPDRS评分均低于西医组(P<0.05)。2组P300潜伏期均较治疗前缩短(P<0.05),中医组P300潜伏期短于西医组(P<0.05)。2组P300波幅值均较治疗前增加(P<0.05),中医组P300波幅值大于西医组(P<0.05)。2组NT-3、5-HT、DA水平均较治疗前升高(P<0.05),中医组NT-3、5-HT、DA水平均高于西医组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:新滋水平肝饮与针刺联合多巴丝肼片治疗肝肾不足型帕金森病效果显著,可进一步减轻临床症状,调节神经递质水平并改善认知功能,且安全性良好。

Objective:To observe the effect of therapy of Xin Zishui Pinggan Decoction and acupuncture combined with Levodopa Benserazide Tablets on Parkinson's disease of liver and kidney insufficiency type.Methods:A total of 112 patients with Parkinson's disease of liver and kidney insufficiency type were randomly divided into the Chinese medicine group and the western medicine group.The western medicine group was treated with Levodopa Benserazide Tablets,and the Chinese medicine group was additionally given Xin Zishui Pinggan Decoction combined with acupuncture based on the treatment of the control group.The two groups were treated for 12 weeks.The clinical effects were compared between the two groups;before and after treatment,the traditional Chinese medicine(TCM)syndrome scores and scores of Unified-Parkinson's Disease Rating Scale(UPDRS)in the two groups were evaluated;the P300 incubation periodand P300 wave amplitude were measured;the neurotransmitters were detected,including dopamine(DA),5-hydroxytryptamin(5-HT)and neurotrophin-3(NT-3);the incidence of adverse reactions duringtreatment was counted.Results:After treatment,the total clinical effective rate in the Chinese medicinegroup was higher than that in the western medicine group(P<0.05).The TCM syndrome scores and UPDRSscores in the two groups were decreased when compared with those before treatment(P<0.05),and theabove two scores in the Chinese medicine group were lower than those in the western medicine group(P<0.05).The P300 incubation period in both groups were shortened when compared with those beforetreatment(P<0.05),and the P300 incubation period in Chinese medicine group was shorter than that in thewestern group(P<0.05).The P300 wave amplitude in the two groups were increased when compared withthose before treatment(P<0.05),and the P300 wave amplitude in the Chinese medicine group was higherthan that in the western medicine group(P<0.05).The levels of NT-3,5-HT and DA in both groups wereincreased when compared with those before treatment(P<0.05),and the above three levels in theChinese medicine group were higher than those in the western medicine group(P<0.05).There was nosignificant difference being found in the comparison of the incidence of adverse reactions between the twogroups(P>0.05).Conclusion:The therapy of Xin Zishui Pinggan Decoction and acupuncture combined withLevodopa Benserazide Tablets has a significant effect on Parkinson's disease of liver and kidney insufficiencytype,which can further mitigate the clinical symptoms,regulate the levels of neurotransmitters and improvethe cognitive function with good safety.