尿毒清颗粒治疗脾肾气虚兼水湿证慢性肾小球肾炎临床研究

Clinical Study on Niaoduqing Granules for Chronic Glomerulonephritis with Spleen-Kidney Qi Deficiency and Water-Dampness Syndrome

目的:观察尿毒清颗粒治疗脾肾气虚兼水湿证慢性肾小球肾炎(CGN)的临床疗效。方法:筛选CGN患者76例,按随机数字表法分为对照组与治疗组各38例。2组均给予常规治疗,对照组加用缬沙坦胶囊治疗,治疗组在对照组基础上加用尿毒清颗粒治疗。2组均治疗4个月。比较2组临床疗效、中医证候评分及肾功能水平。结果:治疗组总有效率为89.47%,对照组为65.79%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组24 h尿蛋白、尿素氮、血肌酐水平比较,差异无统计学意义(P>0.05);治疗后,2组24 h尿蛋白、尿素氮、血肌酐水平均较治疗前降低(P<0.05),且治疗组上述各项指标均低于对照组(P<0.05)。治疗前,2组腰脊酸痛、疲倦乏力、纳少、便溏、尿频、浮肿、小便不利等中医证候评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项证候评分均较治疗前降低(P<0.05),且治疗组各项评分均低于对照组(P<0.05)。结论:在西医常规治疗基础上,尿毒清颗粒可明显提高CGN的临床疗效,有效改善患者中医证候和肾功能。

Objective:To observe the clinical effect of Niaoduqing Granules for chronic glomerulonephritis(CGN)with spleen-kidney qi deficiency and water-dampness syndrome.Methods:A total of 76 cases of CGN patients were screened and divided into the control group and the treatment group according to the random number table method,with 38 cases in each group.Both groups were given routine treatment;the control group was additionally treated with Valsartan Capsules,and the treatment group was additionally treated with Niaoduqing Granules based on the treatment of the control group.Both groups were treated for four months.The clinical effects,and traditional Chinese medicine(TCM)syndrome scores and kidney function levels were compared between the two groups.Results:The total effective rate was 89.47%in the treatment group and 65.79%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of 24-hour urine protein,urea nitrogen and serum creatinine between the two groups(P>0.05);After treatment,the levels of 24-hour urine protein,urea nitrogen and serum creatinine in the twogroups were decreased when compared with those before treatment (P<0.05),and the above indexes inthe treatment group were lower than those in the control group (P<0.05). Before treatment,there was nosignificant difference being found in the comparison of the scores of TCM syndromes such as soreness inlumbar vertebra,fatigue and lack of strength,poor appetite,sloppy stool,frequent urination,edema,and inhibited urination between the two groups (P>0.05);after treatment, the scores of the abovesyndromes in the two groups were significantly decreased when compared with those before treatment (P<0.05), and the scores in the treatment group were lower than those in the control group (P<0.05).Conclusion: Based on the routine treatment of western medicine, Niaoduqing Granules can significantlyenhance the clinical effect,and effectively improve the kidney function and TCM syndromes of patients.