薏苡仁汤浴足联合点阵激光治疗多发性跖疣临床研究

Clinical Study on Foot Bath with Yiyiren Decoction Combined with Fractional Laser for Multiple Plantar Warts

目的:观察薏苡仁汤浴足联合点阵激光治疗多发性跖疣的临床疗效。方法:将82例多发性跖疣湿热瘀滞证患者按随机数字表法分为对照组、观察组各41例,对照组予咪喹莫特乳膏外涂联合点阵激光治疗,观察组予薏苡仁汤浴足联合点阵激光治疗,2组均治疗8周。比较2组临床疗效。治疗前后评定足跖部的疼痛程度[口述分级评分法(VRS)评分]、生活质量[皮肤病生活质量指数(DLQI)评分、简明健康调查量表(SF-36)评分]。观察2种疗法的安全性,统计随访6个月、12个月的复发率。结果:治疗8周后,观察组临床疗效总有效率高于对照组(P<0.05)。2组VRS评分、DLQI评分均较治疗前下降(P<0.05),SF-36评分均较治疗前升高(P<0.05);观察组VRS评分、DLQI评分均低于对照组(P<0.05),SF-36评分高于对照组(P<0.05)。2组不良反应发生率及随访6个月、12个月的复发率比较,差异均无统计学意义(P>0.05)。结论:薏苡仁汤浴足联合点阵激光治疗湿热瘀滞型多发性跖疣的疗效较咪喹莫特乳膏外涂联合点阵激光治疗更为确切,可更好地缓解疼痛,改善患者的生活质量,安全性良好。

Objective:To observe the clinical effect of foot bath with Yiyiren Decoction combined with fractional laser for multiple plantar warts.Methods:A total of 82 cases of patients who had multiple plantar warts with the syndrome of damp-heat and stasis stagnation were divided into the control group and the observation group according to the random number table method,with 41 cases in each group.The control group was treated with the external application of Imiquimod Cream and fractional laser,and the observation group was treated with foot bath with Yiyiren Decoction combined with fractional laser.Both groups were treated for 8 weeks.Clinical effects were compared between the two groups.Before and after treatment,the pain degree of the plantar part was evaluated by Vocal Rating Scale(VRS)scores,and quality of life was evaluated by Dermatology Life Quality Index(DLQI)scores and 36-Item Short Form Survey(SF-36)scores.The safety of the two therapies was observed.The recurrence rates of 6 and 12 months of follow-ups were counted.Results:After 8 weeks of treatment,the total clinical effective rate in the observation group was higher than that in the control group(P<0.05).The scores of VRS and DLQI in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of SF-36 were increased when compared with those before treatment(P<0.05).The scores of VRS and DLQI in the observation group were lower than those in the control group(P<0.05),and the score ofSF-36 was higher than that in the control group(P<0.05).There were no significant difference being foundin the comparison of the incidence of adverse reactions and the recurrence rates of 6 and 12 months offollow-ups between the two groups(P>0.05).Conclusion:In the treatment of multiple plantar warts withthe syndrome of damp-heat and stasis stagnation,foot bath with Yiyiren Decoction combined withfractional laser has a more definite curative effect than the external application of Imiquimod Cream andfractional laser,and can better relieve pain and improve quality of life of patients with good safety.