认知障碍与贫血的相关性研究

Correlation analysis of the cognitive impairment and anemia

目的探讨认知障碍与贫血的相关性。方法选取2012年1月至2021年12月重庆医科大学第一附属医院及2021年某乡镇医院住院老年患者2089例作为研究对象,分为认知正常组(1257例)和认知障碍组(832例)。分析2组患者贫血及相关指标的差异,利用单因素和多因素logistic回归模型分析认知障碍与贫血的相关性。结果2089例患者中存在认知障碍832例(39.8%),存在贫血884例(42.3%)。认知障碍组患者贫血发生率[56.4%(469/832)]明显高于认知正常组[33.0%(415/1257)]。贫血对认知障碍有明显影响(优势比=2.621,95%可信区间:2.188~3.140,P<0.05)。调整性别、年龄、婚姻状况、文化程度、居住情况、现居住地后贫血仍明显影响认知障碍的发生(优势比=2.159,95%可信区间:1.757~2.653,P<0.05)。认知障碍严重程度与贫血严重程度呈正相关(r=0.253,P<0.05)。结论认知障碍与贫血具有相关性,贫血为认知障碍的危险因素。

Objective To explore the correlation between cognitive impairment and anemia.Methods A total of 2089 elderly patients admitted to the First Affiliated Hospital of Chongqing Medical University from January 2012 to December 2021 and a township hospital in 2021 were selected as the study objects,and were divided into the normal cognitive group(1257 cases)and the cognitive impairment group(832 cases).The differences of anemia and related indicators between the two groups were analyzed,and the correlation between cognitive impairment and anemia was analyzed by univariate and multivariate logistic regression models.Results Among the 2089 patients,832(39.8%)had cognitive impairment and 884(42.3%)had anemia.The incidence of anemia in the cognitive impairment group[56.4%(469/832)]was significantly higher than that in the cognitive normal group[33.0%(415/1257)].Anemia had a significant effect on cognitive impairment(OR=2.621,95%CI:2.188-3.140,P<0.05).After adjusting for gender,age,marital status,education,residence,and current place of residence,anemia still significantly affected the occurrence of cognitive impairment(OR=2.159,95%CI:1.757-2.653,P<0.05).The severity of cognitive impairment was positively correlated with the severity of anemia(r=0.253,P<0.05).Conclusion Cognitive impairment is associated with anemia,which is a risk factor for cognitive impairment.