食管癌患者肿瘤异常蛋白与传统肿瘤标志物的相关性分析

Analysis on correlation between tumor abnormal protein and traditional tumor markers in patients with esophageal cancer

目的回顾性分析食管癌(EC)患者肿瘤异常蛋白(TAP)水平,并探讨其与传统肿瘤标志物的相关性。方法选取2021年1-3月该院经病理学检查确诊的EC患者292例,根据是否手术分为术前组与术后组,各146例。采用凝集法测定全血TAP水平,化学发光免疫法检测血清糖类抗原(CA)72-4、癌胚抗原(CEA)、甲胎蛋白(AFP)、铁蛋白(FRT)、CA19-9、CA125、CA50、鳞状细胞癌相关性抗原(SCC)8种传统肿瘤标志物水平,比较两组各指标水平和异常率,并分析各指标的相关性。结果与术前组比较,术后组全血TAP水平和异常率降低,血清CA72-4、CA125水平和异常率升高,差异均有统计学意义(P<0.05);两组间其他肿瘤标志物水平和异常率均无明显差异(P>0.05)。Spearman相关性分析显示:术前组患者中,血清CA19-9与CA50水平呈正相关(r=0.89,P<0.001)且r值最高,其他肿瘤标志物间亦相关(均|r|<0.30);术后组患者中,血清CA19-9与CA50水平呈正相关(r=0.91,P<0.001)且r值最高,全血TAP水平与血清CA72-4及CA125水平呈正相关(均r=0.45,P<0.001)。结论TAP、CA125、CA72-4具有相关性,可能为EC的诊断和治疗监测提供参考。

Objective To retrospectively analyze the level of tumor abnormal protein(TAP)and explore its correlation with the traditional tumor markers in the patients with esophageal cancer(EC).Methods A total of 292 cases of pathologically diagnosed EC in this hospital from January to March 2021 were selected and divided into the preoperative group and postoperative group according to whether perfoming the operation,146 cases in each group.The lectin method was used to detect the whole blood TAP level,and the chemiluminescence immunoassay assay was used to detect the levels of 8 traditional tumor markers,including serum carbohydrate antigen(CA)72-4,carcinoembryonic antigen(CEA),alpha-fetal protein(AFP),ferritin(FRT),CA19-9,CA125,CA50 and squamous cell carcinoma related antigen(SCC),and then the levels of various indicators and abnormality rates were compared between the two groups.Moreover,the correlations among the various indicators were analyzed.Results Compared with the preoperative group,the whole blood TAP level and abnormality rate in the postoperative group were decreased,the levels and abnormality rates of serum CA72-4 and CA125 in the postoperative group were increased,and the differences were statistically sig-nificant(P<0.05).There was no significant difference in the levels and abnormality rates of other indicators between the two groups(P>0.05).The Spearman correlation analysis showed that there was a positive correlation between serum CA19-9 and CA50 levels of the patients in the preoperative group(r=0.89,P<0.001),with the highest r value,and there was also correlations between other tumor markers(all|r|<0.30);the serum CA19-9 level in the patients of the postoperative group was positively correlated with serum CA50 level(r=0.91,P<0.001),with the highest r value,and the whole blood TAP level was positively correlated with serum CA72-4 and CA125 levels(all r=0.45,P<0.001).Conclusion TAP,CA72-4 and CA125 have the correlation,which could provide an important reference for the diagnosis and therapeutic monitoring of EC.