地夸磷索钠联合物理疗法治疗纹眼线致睑板腺功能障碍的临床效果

Clinical efficacy of dequafossol sodium combined with physiotherapy in the treatment of meibomian gland dysfunction caused by striated eyeliner

目的探讨地夸磷索钠联合物理疗法治疗纹眼线致睑板腺功能障碍(MGD)的临床效果。方法前瞻性对照研究。收集郑州市第七人民医院眼科门诊2020年6月至2022年6月纹眼线致睑板腺功能障碍性干眼120例(240眼),随机分为对照组和观察组两组,每组60例(120眼)。对照组给予玻璃酸钠滴眼液滴眼,观察组给予地夸磷索钠滴眼液滴眼。所有患者均联合物理疗法:即超声雾化后再进行每周1次的睑板腺疏通按摩治疗,共8次。记录2、4及8周的疗效指标:眼表疾病指数记录(OSDI)、非侵入式泪膜破裂时间(NIBUT)、角膜荧光素染色评分(CFS)、非侵入式泪河高度测量(NITMH)、泪液分泌试验(SIT)。结果对照组和观察组治疗2、4及8周后,与治疗前相比,OSDI、NIBUT、CFS及睑板腺缺失与治疗前比较均具有统计学意义(F=7.41、3.91、5.21、6.52、6.46、4.20、5.14、6.63,均P<0.05)。治疗2周两组间的OSDI、NIBUT、CFS比较无统计学意义(均P>0.05),治疗4及8周后两组间的OSDI、NIBUT、CFS及睑板腺缺失具有统计学意义(F组间=4.81、60.12、86.01、90.13,均P<0.05)。NITMH、SIT治疗前后及两组间均无统计学意义(F时点=3.48、4.08,均P>0.05;F组间=0.08、0.18,均P>0.05)。结论地夸磷索钠滴眼液结合物理疗法治疗纹眼线所致睑板腺功能障碍的效果确切,干眼症状缓解。

Objective To investigate the clinical effects of dequafossol sodiumcombined with physiotherapy in the treatment of meibomian gland dysfunction(MGD)caused by striated eyeliner.Methods A prospective randomized was controlled to collect 240 eyes of 120 cases with dry eyes with meibomian gland dysfunction caused by eyeliner tattooing from Jun.2020 to Jun.2022 in the Ophthalmology Clinic of Zhengzhou Seventh People’s Hospital.They were randomly divided into two groups,The control group and the observation group,with 120 eyes of 60 cases in each group.The control group was given sodium hyaluronate eye drops,while the observation group was given dexamethasone sodium eye drops.All patients were combined with physical therapy:ultrasound nebulizationfollowed by weekly meibomian gland unclogging massage treatment,a total of 8 times.The therapeutic effects were recorded at 2,4 and 8 weeks:ocular surface disease index(OSDI),non-invasive tear film rupture time(NIBUT),corneal flouorescein score(CFS),non-invasive height measurement of tear river(NIKTMH),tear secretion test(SIT).Results At 2,4 and 8 weeks after treatment,OSDI,NIBUT,CFS and meibomian gland loss in the control group and observation group were significantly higher than those before treatment(F=7.41,3.91,5.21,6.52,6.46,4.20,5.14,6.63;all P<0.05).At 2 weeks after treatment,there was no statistically significant difference in OSDI,NIBUT,and CFS between the two groups(all P>0.05).At 4 and 8 weeks after treatment,there was statistically significant difference in OSDI,NIBUT,CFS,and meibomian duct loss between the two groups(Fgroup=4.81,60.12,86.01,90.13;all P<0.05).There was no statistically significant difference before and after treatment with NITMH and SIT,as well as between the two group(Ftime=3.48,4.08;Fgroup=0.08,0.18;all P>0.05).Conclusion Dexamethasone sodium eye drops combined with physical therapy has a definite effect in the treatment of meibomian gland dysfunction caused by eyeliner,dry eye symptoms are relieved.