间充质干细胞在牙周组织再生中的临床转化研究及应用前景

Clinical translational research and application prospects of mesenchymal stem cells in periodontal tissue regeneration

牙周炎是发生于牙周支持组织的口腔感染性疾病,其破坏牙齿周围软硬组织,最终引发牙齿松动脱落。目前的临床治疗手段可有效控制牙周感染及炎症,但对已遭到破坏的牙周组织,由于受到牙周缺损局部状况和患者全身因素的影响,传统牙周治疗方式尚不能达到满意且稳定的牙周组织再生。近年基于间充质干细胞(mesenchymal stem cells,MSC)的牙周组织再生治疗代表了一种很有前景的治疗策略,在现代再生医学中发挥了不可忽略的作用。本文结合近10年MSC在牙周组织工程中的临床转化应用研究及本课题组前期研究成果,对MSC促进牙周组织再生的机制、MSC在牙周组织再生治疗中的临床前研究、临床转化研究及MSC未来的应用前景进行总结和阐述,以期为后续开展MSC相关研究及临床试验提供参考。

Periodontitis is an oral infectious disease that occurs in the tooth supporting tissues,which damages the soft and hard tissues of the periodontium and eventually results in tooth mobility and loss.Traditional clinical treatment can effectively control the periodontal infection and inflammation.However,as the therapeutic effect depending on the local condition of periodontal defect and the systemic factors of patients,it′s hard to achieve satisfactory and stable periodontal tissue regeneration for damaged periodontal tissues.Recently,as a promising therapeutic strategy in periodontal regeneration,mesenchymal stem cells(MSC)play an important role in modern regenerative medicine.Combined with the clinical translational researches of MSC in periodontal tissue engineering and the research results of our group in the past decade,it is summarized and explained the mechanism of MSC promoting periodontal regeneration,the preclinical and the clinical transformation researches as well as the future application prospects of MSC in periodontal regeneration therapy in this paper.