短链脂肪酸对反刍动物糖和脂代谢及肠道屏障的调控以及其在生产中的应用

Regulation of Short Chain Fatty Acids on Glucose and Lipid Metabolism and Intestinal Barrier in Ruminants and Their Application in Production

动物消化道内复杂多样的微生物群落代谢营养物质产生短链脂肪酸(SCFAs)、生物胺等活性物质参与宿主生理调控。其中,微生物发酵产生的SCFAs以乙酸、丙酸和丁酸为主,且具有参与机体代谢调控、促进胃肠道发育、缓解组织炎症反应、增强免疫功能、调控胃肠道微生物群落及维持肠道屏障功能等多种生物学功能。本文对SCFAs参与反刍动物糖和脂代谢稳态及肠道屏障的调控以及其在动物生产中的应用研究进展进行综述,为把SCFAs开发成功能性饲料添加剂应用在反刍动物生产中提供理论依据。

The complex and diverse microbial communities in animal digestive tract metabolize nutrients and produce short chain fatty acids(SCFAs),bioamines and other active substances involved in host physiological regulation.Among them,the SCFAs produced by microbial fermentation are mainly acetic acid,propionic acid and butyric acid,and have various biological functions such as participating in metabolic regulation,promoting gastrointestinal development,alleviating tissue inflammation,enhancing immune function,regulating gastroin⁃testinal microbial community and maintaining intestinal barrier function.In this paper,the involvement of SC⁃FAs in the regulation of glucose and lipid metabolism homeostasis and intestinal barrier in ruminants and their application in animal production were reviewed,providing a theoretical basis for the development of SCFAs as functional feed additives in ruminant production.