摘要
CONSPECTUS:The current era has witnessed the success of immunotherapy,in particular,immune checkpoint blockade(ICB)therapy,at an unprecedented pace.However,immunotherapy often fails to unleash the antitumor immune response because of the paucity of appropriate therapeutic targets in the complex tumor microenvironment(TME)and the occurrence of intrinsic and adaptive immune resistance of tumor cells.In recent years,we have rationally engineered a set of bioinspired stimuli-activatable nanotherapeutics to circumvent cancer immune resistance and potentiate cancer immunotherapy.
基金
support from the National Natural Science Foundation of China(32050410287 to M.S.,51873228 and 52111530092 to H.Y.)
the International Cooperation Project of Science and Technology Commission of Shanghai Municipality(20430711800)is gratefully acknowledged.
