兽用抗寄生虫药氯氰碘柳胺钠致中毒性视网膜病变1例

Toxic retinopathy caused by veterinary antiparasitic closantel:a case report

1例32岁双眼视力下降2个月女性患者,因自觉眼内寄生虫感染服用多种抗寄生虫药,其中包括兽用药氯氰碘柳胺钠。扫频光源相干光层析成像术检查显示双眼外层视网膜结构消失,视网膜外核层和色素上皮层之间均质弥漫性高反射病变,临床诊断为兽用抗寄生虫药氯氰碘柳胺钠中毒性视网膜病变。因患病时间较长,营养神经、改善循环治疗后视力预后不佳。

A 32-year-old female patient presented with bilateral vision loss for 2 months following her intake of various antiparasitic drugs,including closantel,a veterinary drug,for a self-perceived intraocular parasitic infection.Swept-source optical coherence tomography revealed diffuse hyperreflectivity between the outer nuclear layer and the retinal pigment epithelium,as well as the largely indistinguishable outer retinal layers.This case was clinically diagnosed with veterinary closantel-induced toxic retinopathy and had a poor visual prognosis after nerve nutrition and circulation improvement therapy due to the long duration of the disease.