常规凝血检测指标在诊断复发性流产易栓症患者中的价值

Value of routine coagulation test index in the diagnosis of recurrent spontaneous abortion with thrombophilia

目的探讨常规凝血检测指标在诊断复发性流产易栓症中的价值。方法选取新乡医学院附属医院2020年11月至2022年11月收治的105例复发性流产易栓症患者为观察组,另选取45例健康经产妇为对照组。均检测蛋白S(PS)活性、抗凝血酶(AT)活性、凝血因子XⅡ(FXⅡ)活性和D-二聚体(D-D)等指标水平,并采用受试者工作特征曲线分析上述指标对复发性流产易栓症的预测价值。结果观察组FXⅡ、PS水平低于对照组,D-D水平高于对照组(P<0.05);FXⅡ、PS、D-D对复发性流产易栓症具有一定的预测价值,其中FXⅡ的预测价值最高(AUC=0.981)。结论FXⅡ、PS、D-D对复发性流产易栓症具有一定的预测价值。

Objective To explore the value of routine coagulation test index in the diagnosis of recurrent spontaneous abortion with thrombophilia.Methods A total of 105 patients with recurrent spontaneous abortion with thrombophilia admitted to the Affiliated Hospital of Xinxiang Medical University from November 2020 to November 2022 were selected as the observation group,and 45 healthy multiparas were selected as the control group.The levels of protein S(PS)activity,antithrombin(AT)activity,coagulation factor XⅡ(FXⅡ)activity and D-dimer(D-D)were detected,and the receiver operating characteristic curve was used to analyze the predictive value of the above indicators for recurrent spontaneous abortion with thrombophilia.Results The levels of FXⅡand PS in the observation group were lower than those in the control group,and the level of D-D was higher than that in the control group(P<0.05).FXⅡ,PS and D-D had certain predictive value for recurrent spontaneous abortion with thrombophilia,among which FXⅡhad the highest predictive value(AUC=0.981).Conclusion FXⅡ,PS and D-D have certain predictive value for recurrent spontaneous abortion with thrombophilia.