无创正压通气治疗重度支气管哮喘的疗效分析

Analysis of the efficacy of noninvasive positive pressure ventilation in the treatment of severe bronchial asthma

目的分析无创正压通气治疗重度支气管哮喘的疗效。方法100例重度支气管哮喘患者,采用随机数字表法分为对照组及观察组,每组50例。对照组患者给予常规药物+鼻导管吸氧治疗,观察组在常规药物基础上增加无创正压通气治疗。比较两组哮喘控制时间、住院时间,治疗前后的血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))]、肺功能监测指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)],治疗效果。结果观察组患者哮喘控制时间为(7.32±1.32)d、住院时间为(12.34±1.62)d,均短于对照组的(9.12±2.21)、(14.11±2.21)d,差异具有统计学意义(P<0.05)。治疗后,两组患者的PaO_(2)、SaO_(2)、FEV1、FVC均高于本组治疗前,PaCO_(2)低于本组治疗前,且观察组患者的PaO_(2)(82.56±6.21)mm Hg(1 mm Hg=0.133 kPa)、SaO_(2)(94.56±3.21)%、FEV1(2.32±0.32)L、FVC(3.34±0.62)L均高于对照组的(75.51±3.14)mm Hg、(91.34±3.01)%、(1.68±0.69)L、(2.67±0.42)L,PaCO_(2)(36.56±2.21)mm Hg低于对照组的(45.57±3.25)mm Hg,差异具有统计学意义(P<0.05)。观察组患者总有效率98.00%高于对照组的82.00%,差异具有统计学意义(P<0.05)。结论常规药物联合无创正压通气对于重度支气管哮喘的治疗效果确切,可有效改善患者的肺功能和血气分析指标,缩短治疗时间,值得推广和应用。

Objective To analyze the efficacy of noninvasive positive pressure ventilation in the treatment of severe bronchial asthma.Methods A total of 100 patients with severe bronchial asthma were randomly divided into control group and observation group by digital table method,with 50 cases in each group.Patients in the control group was given conventional drug therapy and nasal catheter oxygen inhalation,and patients in the observation group was given noninvasive positive pressure ventilation on the basis of conventional drug therapy.Both groups were compared in terms of asthma control time,hospital stay,blood gas analysis indexes[partial pressure of arterial oxygen(PaO_(2)),partial pressure of arterial carbon dioxide(PaCO_(2)),arterial oxygen saturation(SaO_(2))],pulmonary function monitoring indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC)]before and after treatment,and therapeutic effect.Results The asthma control time and hospital stay of the observation group were(7.32±1.32)and(12.34±1.62)d,both of which were shorter than those of(9.12±2.21)and(14.11±2.21)d of the control group,and the differences were statistically significant(P<0.05).After treatment,PaO_(2),SaO_(2),FEV1 and FVC in both groups were higher than those before treatment in this group,while PaCO_(2)was lower than that before treatment in this group;the observation group had PaO_(2)of(82.56±6.21)mm Hg(1 mm Hg=0.133 kPa),SaO_(2)of(94.56±3.21)%,FEV1 of(2.32±0.32)L and FVC of(3.34±0.62)L,which were higher than those of(75.51±3.14)mm Hg,(91.34±3.01)%,(1.68±0.69)L and(2.67±0.42)L in the control group;PaCO_(2)of(36.56±2.21)mm Hg in the observation group was lower than that of(45.57±3.25)mm Hg in the control group;the differences were statistically significant(P<0.05).The total effective rate of 98.00%in the observation group was higher than that of 82.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Conventional drugs combined with noninvasive positive pressure ventilation is effective in the treatment of severe bronchial asthma,which can effectively improve patients'pulmonary function and blood gas analysis index and shorten the treatment time,so it is worth promoting and applying.