紫杉醇联合顺铂治疗晚期食道癌的临床效果分析

Clinical analysis of paclitaxel combined with cisplatin in the treatment of advanced esophageal cancer

目的分析紫杉醇联合顺铂治疗晚期食道癌的临床效果。方法98例晚期食道癌患者,按照治疗方案不同分为对照组和观察组,每组49例。对照组患者采用顺铂联合氟尿嘧啶进行治疗,观察组患者采用顺铂联合紫杉醇进行治疗。比较两组患者治疗前后的肿瘤直径与垂直直径、治疗效果、随访期(截止2021年6月)生存时间及肿瘤进展时间。结果治疗后,观察组患者肿瘤直径(10.55±1.25)mm、垂直直径(13.37±1.56)mm均小于对照组的(14.06±1.87)、(16.80±1.81)mm,差异均具有统计学意义(P<0.05)。观察组临床治疗总有效率93.88%高于对照组的67.35%,差异具有统计学意义(P<0.05)。观察组患者随访期生存时间(10.88±2.12)个月、肿瘤进展时间(6.82±1.54)个月均显著长于对照组的(9.02±1.65)、(4.56±1.17)个月,差异具有统计学意义(P<0.05)。结论紫杉醇联合顺铂治疗晚期食道癌疗效显著,治疗后瘤体直径明显缩小,疾病控制率显著提高,值得临床推广应用。

Objective To analyze the clinical effect of paclitaxel combined with cisplatin in the treatment of advanced esophageal cancer.Methods A total of 98 patients with advanced esophageal cancer were divided into control group and observation group according to different treatment regiments,with 49 cases in each group.The control group was treated with cisplatin and fluorouracil,and the observation group was treated with cisplatin and paclitaxel.The tumor diameter and vertical diameter before and after treatment,therapeutic effect,survival time and time to progression at follow-up(up to June 2021)were compared between the two groups.Results After treatment,the tumor diameter and vertical diameter of the observation group were(10.55±1.25)and(13.37±1.56)mm,which were both smaller than those of(14.06±1.87)and(16.80±1.81)mm of the control group,and the differences were statistically significant(P<0.05).The total effective rate of 93.88%in the observation group was higher than that of 67.35%in the control group,and the difference was statistically significant(P<0.05).The survival time of(10.88±2.12)months and time to progression of(6.82±1.54)months in the observation group were significantly longer than those of(9.02±1.65)and(4.56±1.17)months in the control group,and the differences were statistically significant(P<0.05).Conclusion Paclitaxel combined with cisplatin has significant effect in the treatment of advanced esophageal cancer,the tumor diameter is significantly reduced after treatment,and the disease control rate is significantly improved,which is worthy of clinical popularization and application.