膜控储库型缓释给药系统在生殖健康领域的研究进展

Research progress of membrane-controlled reservoir sustained-release drug delivery systems for reproductive health

当今中国人口老龄化问题日益严重,而在国家提倡三孩政策下的女性生育力又不断下降,不论是中老年女性还是育龄女性都面临着生殖健康问题。传统口服制剂作用时间短且有的品种还存在生物利用度低的问题,长效缓释制剂具有使用方便、血药浓度稳定、安全性更高等优点,其开发为更多的生殖避孕药具研发和应用提供了理论基础与技术支持。在数十年的研发过程中诞生了多种不同类型的递药系统,其中以聚合物为基质的膜控储库型制剂作为一种常见的药物缓释系统,多用于生殖健康,且具有广阔的市场前景。本文就生殖健康领域中以聚合物为载体递送药物的膜控储库型制剂做简要综述,重点探讨了基于该种系统的聚合物材料选择、体外释放模型、制剂类型及研究进展、面临的挑战共四个关键问题,为今后开发相关药具提供借鉴。

Nowadays,the aging of China's population is becoming increasingly serious,and fertility of women under the national three-child policy is declining,both middle-aged and elderly women and women of childbearing age are facing reproductive health problems.Traditional oral preparations have a short acting time and some varieties have low bioavailability problems,while the long-acting sustained-release preparations have the advantages of convenient use,stable blood drug concentration and higher safety.Their development provides theoretical basis and technical support for the development and application of reproductive contraceptives.In the decades of research,a variety of different drug delivery systems have been born.Among them,the polymer-based membrane-controlled reservoir preparations,as a common drug sustained-release system,is mostly used in reproductive health and has broad market prospects.In this paper,polymer-based membrane-controlled reservoir drug delivery systems in the field of reproductive health was briefly reviewed,and four key issues including polymer material selection,in vitro drug release model,preparation types and research progress,and challenges were discussed,which can provide reference for the development of related contraceptives in the future.