肺动脉高压的细胞炎症研究进展

Progress in Cellular Inflammation of Pulmonary Arterial Hypertension

动脉型肺动脉高压(pulmonary arterial hypertension,PAH)是一种罕见的进行性综合征,由肺血管阻力的进行性增加和最终的右心室衰竭引起,仍是一种无法治愈、死亡率高的疾病,炎症在发病及进展中起关键作用。在PAH患者的肺活检组织中,几乎所有炎症细胞谱系都在重塑的肺血管系统附近被检测到。多种细胞因子、趋化因子及自身抗体在PAH动物模型和PAH患者中被证实,并与临床结局相关。对炎症细胞、血管细胞和炎症介质之间相互作用的认识可能为开发新型、安全、有效的PAH免疫靶向治疗提供重要线索。

Pulmonary arterial hypertension(PAH),a rare progressive syndrome caused by progressive increase in pulmonary vascular resistance and eventually right ventricular failure,remains an incurable,highly mortal disease in which inflammation plays a key role in its onset and progression.In lung biopsy tissue from patients with PAH,almost all lineages of inflammatory cells are detected near the remodeled pulmonary vascular system.A variety of cytokines,chemokines,and autoantibodies have been demonstrated in animal models of PAH and in patients with PAH,and are associated with clinical outcomes.Understanding the interactions between inflammatory cells,vascular cells,and inflammatory mediators may provide important clues for the development of novel,safe,and effective immunotargeted therapies for PAH.