基于多组学的真菌病毒与寄主真菌互作的研究进展

Advances in the interaction between mycoviruses and host fungi based on multi-omics

阐述了多组学包括代谢组学、转录组学和蛋白组学技术的原理、方法和步骤,并结合其在弱毒真菌病毒中研究的案例,全面分析了代谢组学、转录组学和蛋白组学技术在真菌病毒与寄主真菌互作中的研究现状、未来的研究方向以及具备的高灵敏度、高通量优势,有助于深度探究真菌病毒对寄主真菌的影响及其分子机制,并为判断真菌病毒能否作为植物真菌病害生物防治因子提供方法和思路。

The principles,methods and steps of multi-omics,including metabonomics,transcriptomics and proteomics technologies,were described,and the current status,future research directions and the advantages of high sensitivity and high throughput of metabonomics,transcriptomics and proteomics technologies in the interaction between mycoviruses and host fungi were comprehensively analyzed in combination with their research cases in hypovirulent mycoviruses.This review is helpful for deep exploration of the effects of mycoviruses on host fungi and their molecular mechanisms,and provides methods and ideas to determine whether mycoviruses can be used as biological factors for control of plant fungal diseases.