放射复合伤的研究进展与展望

Advances and prospect in research of radiation combined injuries

放射损伤合并烧伤、冲击伤、创伤等不同性质致伤因素所致复合性损伤称为放射复合伤,是战时核爆炸与平时核事故等情况下发生的一种重要的、特殊的损伤,其救治是一个突出的医学难题。近年来,相关机构围绕放射复合伤的复合效应机制与救治策略开展了持续深入研究。在药物防治方面,已经筛选鉴定出多种有效提升动物存活率的治疗用药,并且联合用药的理念已得到验证。在其难愈创面促愈方面,细胞治疗及以炎症调控为思路的干预手段均取得较好效果。后续需要将新理论、新方法、新模型等引入放射复合伤领域,从而持续深入推进其研究。

Radiation combined injury(RCI)is referred to conditions which radiation injury is coupled with other insults such as burns,blast,wounds,or infection.RCI often occurs as major injuries during nuclear weapon explosion in the war as well as severe nuclear accidents in peacetime.Treatment of RCI is one troublesome problem because of both systemic aggravating effects and local delayed wound healing.Previously,some research institutes have focused on RCI and made important contributions to understanding the combined effects and setting treatment strategy.In the aspect of medical treatment,several drugs have been selected and identified as therapeutic drugs for improving animal survived rate,and the concept of poly-pharmacy approach has been verified.In the aspect of treating delayed wound healing of RCI,both cell therapy and intervention means aiming regulating wound inflammation have been proved effective.In future,the new theory,new technology and new model should be introduced to RCI research field,then promote in-depth study of RCI.