干细胞源性外泌体在创伤修复中免疫作用的研究进展

Progress of immune role of stem cell-derived exosomes in wound repair

机体受到严重创伤后,免疫系统常表现为功能障碍,且创伤越重表现越明显,影响机体修复。干细胞源性外泌体是干细胞产生的一种细胞间的非脂溶性载体,其可通过抑制过度炎性反应和减少免疫细胞凋亡等功能来调节机体免疫异常。本文对干细胞源性外泌体在创伤修复中的免疫调节作用进行综述,旨在总结外泌体在免疫调节中的作用机制。

The immune system is often characterized by dysfunction after the body suffered from severe trauma,the body's repair was affected obviously from the heavy trauma performance.Stem cell-derived exosomes are non-fat-soluble intercellular vector produced by stem cells,which can regulate immune abnormalities by inhibiting excessive inflammatory response and reducing immune cell apoptosis.The immunomodulatory role of stem cell-derived exosomes in wound repair are systematically reviewed,and to summarize the mechanism of exosomes in immune regulation.