基于SS-OCT分析眼轴长度与眼前节参数的相关性

Correlation between axial lengths and anterior segment parameters evaluated by swept-source optical coherence tomography

目的:利用扫频源光相干断层扫描成像(SS-OCT)观察与探讨眼轴长度(AL)与眼前节相关参数的相关性。方法:横断面临床研究,纳入2022-01-01/03-31在郑州大学第一附属医院眼科门诊招募的不同程度近视的成人志愿者109例,依据AL将受检者分为4组:A组(AL≤24.0mm)、B组(24.0mm26.0mm)。SS-OCT(视微影像)进行眼前节检查,对中央角膜厚度(CCT)、晶状体厚度(LT),前房参数:中央前房深度(ACD)、前房宽度(ACW)、房角开放距离(AOD500)、房角隐窝面积(ARA500)、小梁网-虹膜间面积(TISA500)、小梁虹膜夹角(TIA500),晶状体矢高(CLR)进行记录,并分析其与AL、等效球镜度数(SE)的关系。结果:四组CCT比较无差异(P>0.05)。四组SE、LT、ACD、ACW、AOD500、ARA500、TISA500、TIA500、CLR比较有差异(均P<0.01)。SE、LT与AL呈负相关(r=-0.75、-0.41,均P<0.01);ACD、ACW、CLR与AL呈正相关(r=0.58、0.45、0.54,均P<0.01);AOD500、ARA500、TISA500、TIA500(颞侧及鼻侧)与AL呈正相关(均P<0.01)。ACD、CLR与SE呈负相关(r=-0.21、-0.25,均P<0.01),LT与SE呈正相关(r=0.21,P<0.05)。结论:随着AL的增加CCT无明显改变,ACD、ACW及房角开放程度则增加,晶状体位置后移,LT变薄。

AIM:To evaluate the correlation between axial lengths and anterior segment parameters using swept-source optical coherence tomography(SS-OCT).METHODS:For the cross-sectional clinical study,a total of 109 adult volunteers with different degrees of myopia recruited from January 1,2022,to March 31,2022,at the ophthalmology clinic of the First Affiliated Hospital of Zhengzhou University were included.Participants were divided into 4 groups based on axial length(AL):group A(AL≤24.0mm),group B(24.0mm<AL≤25.0mm),group C(25.0mm<AL≤26.0mm)and group D(AL>26.0mm).Anterior segment examinations were performed using SS-OCT,including:central corneal thickness(CCT),lens thickness(LT),anterior chamber depth(ACD),anterior chamber width(ACW),angle opening distance(AOD500),angle recess area(ARA500),trabecular iris space area(TISA500),trabecular iris angle(TIA500),crystalline lens rise(CLR).The relationships between these data and AL,spherical equivalent(SE)were analyzed.RESULTS:There was no difference in the comparison of CCT among the four groups(P>0.05).There were differences in SE,LT,ACD,ACW,AOD500,ARA500,TISA500,TIA500 and CLR among the four groups(all P<0.01).SE and LT were negatively correlated with AL(r=-0.75,-0.41,all P<0.01);ACD,ACW and CLR were positively correlated with AL(r=0.58,0.45,0.54,all P<0.01);AOD500,ARA500,TISA500 and TIA500(temporal and nasal side)were positively correlated with AL(all P<0.01).ACD and CLR were negatively correlated with SE(r=-0.21,-0.25,all P<0.01),and LT was positively correlated with SE(r=0.21,P<0.05).CONCLUSION:As AL increases,CCT remains unchanged while the ACD and ACW increase.The position of the crystalline lens moves backward and LT decreases.