多元化管理模式对高尿酸血症患者糖脂代谢及Hcy水平的影响

Effect of diversified management mode on glucolipid metabolism and Hcy level in patients with hyperuricemia

目的探讨多元化管理模式在高尿酸血症患者中的效果及对糖脂代谢、同型半胱氨酸(Hcy)的影响。方法在甘肃省嘉峪关市酒钢医院2020年1月至2020年12月于甘肃省嘉峪关市酒钢医院参加体检的高尿酸血症患者中选取18206例,按照抽签随机分组分为两组,各9103例,研究组采用多元化管理模式干预,对照组采用常规管理模式干预,对比两组干预前后疾病认知水平、糖脂代谢指标[空腹血糖(FBG)、餐后2 h血糖水平(2 h PBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)]、血清指标[尿酸(UA)水平、同型半胱氨酸(Hcy)水平]。结果干预后研究组FBG、2h PBG、HbA1c均低于对照组,差异有统计学意义(t=44.807,31.767,58.337,P<0.05);干预后研究组TC、TG、LDL水平均低于对照组,差异有统计学意义(t=79.310,47.521,46.719,P<0.05);干预后研究组UA、Hcy水平均低于对照组,差异有统计学意义(t=533.159,134.254,P<0.05);干预后研究组≥60岁患者患者认知、信念、行为及总分均高于对照组,差异有统计学意义(t=68.693,98.182,74.328,120.210,P<0.05),干预后研究组<60岁患者患者认知、信念、行为及总分均高于对照组,差异有统计学意义(t=336.478,477.020,247.575,293.594,P<0.05)。结论在高尿酸血症中采取多元化管理模式能够改善血糖、血脂代谢水平,值得临床推广应用。

Objective To investigate the effect of diversified management mode in patients with hyperuricemia and its effects on glycolipid metabolism and homocysteine(Hcy).Methods A total of 18206 patients with hyperuricemia who participated in physical examination in Jiugang Hospital of Jiayuguan City,Gansu Province from January 2020 to December 2020 were selected and randomly divided into two groups according to lottery,with 9103 cases in each group.The study group adopted diversified management mode intervention,while the control group adopted conventional management mode intervention.Disease cognition level,glucose and lipid metabolism indexes[fasting blood glucose(FBG)],postprandial 2 were compared between the two groups before and after intervention 2 h Blood glucose level(2 h PBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),serum markers[uric acid(UA)level,homocysteine(Hcy)level]were compared.Results After intervention,FBG,2h PBG and HbA1c in the study group were lower than those in the control group,and the difference was statistically significant(t=44.807,31.767,58.337,P<0.05).After intervention,the levels of TC,TG and LDL in the study group were lower than those in the control group,and the differences were statistically significant(t=79.310,47.521,46.719,P<0.05).After intervention,the levels of UA and Hcy in the study group were lower than those in the control group,and the difference was statistically significant(t=533.159,134.254,P<0.05).After intervention,the cognition,belief,behavior,and total score of patients≥60 years old in the study group were higher than those in the control group,and the difference was statistically significant(t=68.693,98.182,74.328,120.210,P<0.05).The cognition,belief,behavior,and total score of patients<60 years old in the study group after intervention were higher than those in the control group.The difference was statistically significant(t=336.478,477.020,247.575,293.594,P<0.05).Conclusion Adopting a diversified management mode in hyperuricemia can improve the level of blood glucose and lipid metabolism,which is worthy of clinical application.