益气疏风汤联合针灸治疗慢性荨麻疹的效果及其对血清IgE、IL⁃31、IL⁃33的影响

Effect of Yiqishufeng Decoction combined with acupuncture on chronic urticaria and its influence on serum IgE,IL⁃31 and IL⁃33

目的 探讨益气疏风汤联合针灸治疗慢性荨麻疹的效果及其对血清免疫球蛋白E(IgE)、白介素31(IL-31)、白介素33(IL-33)的影响。方法 选取2019年6月至2022年6月宿松县人民医院皮肤科就诊的慢性荨麻疹患者124例作为研究对象,所有患者均给予常规西药治疗,在此基础上分两组,针灸组(n=60)和针灸+中药组(n=64),针灸组采用针灸治疗,针灸+中药组采用益气疏风汤联合针灸治疗,两组均治疗4 w。观察比较两组症状及体征评分情况、临床疗效、炎症反应情况、不良反应及复发率。结果 治疗4 w,两组风团大小、风团数量、风团发生次数、瘙痒程度、风团持续时间评分下降,针灸+中药组风团大小、风团数量、风团发生次数、瘙痒程度、风团持续时间评分低于针灸组,差异有统计学意义(t=2.980、2.667、2.396、2.420、3.077,P<0.05);针灸+中药组临床有效率为95.31%,高于针灸组的81.66%,差异有统计学意义(χ^(2)=5.757,P<0.05);两组血清IgE、IL-31、IL-33水平下降,针灸+中药组血清IgE、IL-31、IL-33水平低于针灸组,差异有统计学意义(t=2.820、7.756、10.254,P<0.05);针灸+中药组不良反应总发率、复发率均显著低于针灸组,差异有统计学意义(χ^(2)=4.353、4.139,P<0.05)。结论 益气疏风汤联合针灸治疗慢性荨麻疹的效果显著,改善其中医症状及体征,可以调节免疫指标,降低患者机体炎症因子水平,减少复发。

Objective To investigate the effect of Yiqi Shufeng Decoction combined with acu⁃puncture on chronic urticaria and its influence on serum immunoglobulin E(IgE),interleukin 31(IL⁃31)and interleukin 33(IL⁃33).Methods 124 patients with chronic urticaria who were treated in the Department of Dermatology of Susong County People's Hospital from June 2019 to June 2022 were selected as the research objects.All patients were given conventional western medicine treatment.On this basis,they were divided into two groups,the acupuncture group(n=60)and the acupuncture+Chinese medicine group(n=64).Both groups were treated for 4 weeks.The acupuncture group was treated with acupuncture and moxibustion,and the acupuncture+Chinese medicine group was treated with Yiqi Shufeng Decoction combined with acupunc⁃ture and moxibustion.The scores of symptoms and signs,clinical efficacy,inflammatory response,adverse re⁃actions,and recurrence rate were observed and compared between the two groups.Results After 4 weeks of treatment,the scores of wheal size,number of wheals,itching degree,and duration of wheals in the two groups decreased.The scores of wind mass size,wind mass number,wind mass occurrence frequency,itching degree and wind mass duration in the acupuncture and moxibustion+Chinese medicine group were lower than those in the acupuncture and moxibustion group,the difference was statistically significant(t=2.980,2.667,2.396,2.420,3.077,P<0.05).The levels of serum IgE,IL⁃31 and IL⁃33 in the acupuncture+Chinese medicine group were lower than those in the acupuncture group,the difference was statistically significant(χ^(2)=5.757,P<0.05).The total incidence and recurrence rate of adverse reactions in the acupuncture+Chinese medicine group were significantly lower than those in the acupuncture group,the difference was statistically significant(t=2.820,7.756,10.254,P<0.05).The total incidence and recurrence rate of adverse reactions in the combined treatment group were significantly lower than those in the western medicine group,the difference was statistically signifi⁃cant(χ^(2)=4.353,4.139,P<0.05).Conclusion Yiqi Shufeng Decoction combined with acupuncture and moxi⁃bustion has a significant effect in the treatment of chronic urticaria,improving its TCM symptoms and signs,reg⁃ulating immune indicators,reducing the level of inflammatory factors in patients,and reducing recurrence.