新生儿腹部手术史与青少年肠易激综合征相关性研究

Relationship between neonatal abdominal surgery history and adolescent irritable bowel syndrome

肠易激综合征(irritable bowel syndrome,IBS)是儿童人群的常见病和多发病,在我国和世界范围内发病率高,严重影响患者的生活质量,对儿童医疗保健系统造成很大的负担。IBS与新生儿腹部手术史密切相关,对儿童肠道的侵入性操作可能通过低度炎症促进肠道高敏感、干扰肠道菌群、肠道微生物感染、胃肠动力异常、应激等机制参与IBS的发生与发展。此文就小儿腹部手术史在IBS患儿发病中的作用及相关临床干预方法进行简要概述,为IBS的预防、治疗和后续研究提供理论参考。

Irritable bowel syndrome(IBS)is a kind of common and frequently-occurring disease among children.Of great morbidity nationwide and worldwide,IBS affects the quality of life of patients immensely and extensively,and puts a huge burden on the children's health care system.IBS is closely related to neonatal abdominal surgery history,which promotes the onset and development of IBS through building up visceral hypersensitivity,interfering with intestinal microbiota,microbial infection,gastrointestinal motility abnormality and stress.Here,the mechanism of neonatal abdominal surgery history involved in IBS and clinical treatments in relevance were reviewed,hoping to collect theoretical bases for IBS prevention,treatments and researches in future.